CLINICAL STATUS AND BRAIN FUNCTIONING IN ADOLESCENTS AND ADULTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是评估处于精神分裂症不同发展阶段的受试者。受试者可能是“前驱症状”(高临床风险)、首发、慢性或健康对照，这为研究人员提供了一个广阔的视角和关于进展的表型标志物和预测因素的数据库。这项研究的目的是将精神分裂症疾病进展的临床、认知、神经成像、电生理、激素和遗传标记与理解潜在的神经回路可能受到的干扰联系起来。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of this study is to evaluate subjects who are at various stages of progression to schizophrenia. Subjects may be "prodromal" (high clinical risk), first episode, chronic, or healthy controls, which gives the investigators a broad perspective and database on phenotypic markers and predictors of progression. The study aims to link clinical, cognitive, neuroimaging, electrophysiological, hormonal and genetic markers of schizophrenia disease progression to the understanding of how the underlying neural circuits may be disturbed.