Vulnerability to Progression Schizophrenia

精神分裂症进展的脆弱性

• 批准号: 7929313
• 负责人: Robert W McCarley
• 金额: $ 30.5万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7929313
• 关键词: Vulnerability; Progression; Schizophrenia

DESCRIPTION (provided by applicant): The central theme of the application for a Boston Center for Intervention Development and Applied Research (CIDAR) is "Vulnerability to Progression in Schizophrenia". We see two major strengths of the proposal. First we study subjects who are at various stages of progression of the disorder, prodromal, first episode and chronic, giving us a broad perspective and large database on phenotypic markers and predictors of progression. Moreover, prodromes and first episode individuals will be evaluated in a prospective longitudinal study. A second major strength, in our view, is our plan to link clinical, cognitive, neuroimaging, electrophysiological, hormonal and genetic markers of SZ disease progression to the understanding of how the underlying neural circuits may be disturbed. We do this by investigating the expression of genes of interest in specific cellular populations in post-mortem material and evaluating genetic association of the relevant genes with progression indices from each Project. Four projects, each with an experienced investigator as PI, all evaluate the same group of subjects so as to bring multiple perspectives on the markers and predictors of progression. Project 1. "Functional anatomy of neurocognitive deterioration in schizophrenia", uses neuropsychological and fMRI evaluations. Project 2, "Hormones, memory & sex effects in illness progression in schizophrenia", evaluates hormones and gender differences in schizophrenia. Project 3, "Electrophysiological and MRI gray matter markers and predictors of progression", uses event-related potentials (ERPs) and MRI gray matter measures to evaluate progression, often conjoint, in these two domains. Project 4, "Vulnerability to white matter progression in schizophrenia" uses diffusion tensor imaging evaluations of white matter. A long-standing history of previous successful collaborations and work on joint projects by these project PIs will facilitate the synergistic interactions essential for knitting together data from the different methodological and conceptual domains. The Center mechanism brings added value to this work since no single R01 award could support: 1) the translational gene expression and genetics endeavor in the cores that specifically links to each Project's clinical research findings; 2) the large-scale subject recruiting needed for each project; 3) the extensive neuroimaging work; 4) the linking together of the Project's diverse technologies and levels of analysis on the same subjects, affording a rich opportunity to understand interrelationships of findings from different domains.

描述（由申请人提供）：波士顿中心申请的中心主题 干预开发和应用研究（CIDAR）是“进展的脆弱性” 精神分裂症”。我们看到该提案的两个主要优点。首先，我们研究处于不同状态的受试者 该疾病的进展阶段、前驱期、首发期和慢性期，为我们提供了广泛的了解 关于表型标记和进展预测因子的观点和大型数据库。而且， 前驱症状和首发个体将在前瞻性纵向研究中进行评估。一秒钟 我们认为，主要优势是我们计划将临床、认知、神经影像、电生理、 SZ 疾病进展的激素和遗传标记，以了解潜在的机制 神经回路可能会受到干扰。我们通过研究感兴趣的基因的表达来做到这一点 死后材料中的特定细胞群并评估相关的遗传关联 具有每个项目的进展指数的基因。 四个项目，每个项目都有一位经验丰富的研究者作为 PI，都评估同一组受试者，因此 以便对进展的标志物和预测因素带来多种视角。项目1.“功能性 精神分裂症神经认知恶化的解剖学”，使用神经心理学和功能磁共振成像 评价。项目 2，“激素、记忆和性对精神分裂症疾病进展的影响”， 评估精神分裂症的激素和性别差异。项目3，“电生理学和MRI 灰质标记物和进展预测因子”，使用事件相关电位 (ERP) 和 MRI 灰质 评估这两个领域进展的重要衡量标准，通常是联合的。项目 4，“漏洞 精神分裂症的白质进展”使用白质的扩散张量成像评估。 这些项目之前的成功合作和联合项目工作有着悠久的历史 PI 将促进协同互动，这对于将来自不同领域的数据结合在一起至关重要 方法论和概念领域。 中心机制为这项工作带来了附加值，因为没有任何一个 R01 奖项可以支持：1) 翻译基因表达和遗传学在与每个具体相关的核心中的努力 项目的临床研究成果； 2）各项目所需的大规模课题招募； 3） 广泛的神经影像学工作； 4）将项目的不同技术和水平连接在一起 对同一主题的分析，提供了丰富的机会来理解研究结果的相互关系 来自不同的领域。