Vulnerability to Progression Schizophrenia
精神分裂症进展的脆弱性
基本信息
- 批准号:7929313
- 负责人:
- 金额:$ 30.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-30 至 2011-09-29
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): The central theme of the application for a Boston Center for
Intervention Development and Applied Research (CIDAR) is "Vulnerability to Progression in
Schizophrenia". We see two major strengths of the proposal. First we study subjects who are at various
stages of progression of the disorder, prodromal, first episode and chronic, giving us a broad
perspective and large database on phenotypic markers and predictors of progression. Moreover,
prodromes and first episode individuals will be evaluated in a prospective longitudinal study. A second
major strength, in our view, is our plan to link clinical, cognitive, neuroimaging, electrophysiological,
hormonal and genetic markers of SZ disease progression to the understanding of how the underlying
neural circuits may be disturbed. We do this by investigating the expression of genes of interest in
specific cellular populations in post-mortem material and evaluating genetic association of the relevant
genes with progression indices from each Project.
Four projects, each with an experienced investigator as PI, all evaluate the same group of subjects so
as to bring multiple perspectives on the markers and predictors of progression. Project 1. "Functional
anatomy of neurocognitive deterioration in schizophrenia", uses neuropsychological and fMRI
evaluations. Project 2, "Hormones, memory & sex effects in illness progression in schizophrenia",
evaluates hormones and gender differences in schizophrenia. Project 3, "Electrophysiological and MRI
gray matter markers and predictors of progression", uses event-related potentials (ERPs) and MRI gray
matter measures to evaluate progression, often conjoint, in these two domains. Project 4, "Vulnerability
to white matter progression in schizophrenia" uses diffusion tensor imaging evaluations of white matter.
A long-standing history of previous successful collaborations and work on joint projects by these project
PIs will facilitate the synergistic interactions essential for knitting together data from the different
methodological and conceptual domains.
The Center mechanism brings added value to this work since no single R01 award could support: 1)
the translational gene expression and genetics endeavor in the cores that specifically links to each
Project's clinical research findings; 2) the large-scale subject recruiting needed for each project; 3) the
extensive neuroimaging work; 4) the linking together of the Project's diverse technologies and levels of
analysis on the same subjects, affording a rich opportunity to understand interrelationships of findings
from different domains.
描述(由申请人提供):申请波士顿中心的中心主题
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Robert W McCarley其他文献
P300 as An Index of Transition to Psychosis and of Remission: Data from A Clinical High Risk for Psychosis Study and Review of Literature.
P300 作为向精神病转变和缓解的指标:来自精神病临床高风险研究和文献综述的数据。
- DOI:
10.1016/j.schres.2019.02.014 - 发表时间:
2020 - 期刊:
- 影响因子:4.5
- 作者:
Yingying Tang;Junjie Wang;Tianhong Zhang;Lihua Xu;Zhenying Qian;Huiru Cui;Xiaochen Tang;Huijun Li;Susan Whitfield-Gabrieli;Martha E Shenton;Larry J Seidman;Robert W McCarley;Matcheri S Keshavan;William S Stone;Jijun Wang;Margaret A Niznikiewicz - 通讯作者:
Margaret A Niznikiewicz
Robert W McCarley的其他文献
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{{ truncateString('Robert W McCarley', 18)}}的其他基金
Basal Forebrain Cellular Mechanisms of Cortical Activation
皮质激活的基底前脑细胞机制
- 批准号:
8242210 - 财政年份:2011
- 资助金额:
$ 30.5万 - 项目类别:
Basal Forebrain Cellular Mechanisms of Cortical Activation
皮质激活的基底前脑细胞机制
- 批准号:
8413399 - 财政年份:2011
- 资助金额:
$ 30.5万 - 项目类别:
Basal Forebrain Cellular Mechanisms of Cortical Activation
皮质激活的基底前脑细胞机制
- 批准号:
8598052 - 财政年份:2011
- 资助金额:
$ 30.5万 - 项目类别:
PROJECT 3: ELECTROPHYSIOLOGICAL & GRAY MATTER MARKERS & PREDICTORS OF PROGRESSION
项目 3:电生理学
- 批准号:
8136028 - 财政年份:2010
- 资助金额:
$ 30.5万 - 项目类别:
相似海外基金
PROJECT 4: VULNERABILITY TO WHITE MATTER PROGRESSION IN SCHIZOPHRENIA
项目 4:精神分裂症患者白质进展的脆弱性
- 批准号:
8136029 - 财政年份:2010
- 资助金额:
$ 30.5万 - 项目类别:
PROJECT 4: VULNERABILITY TO WHITE MATTER PROGRESSION IN SCHIZOPHRENIA
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- 批准号:
7279684 - 财政年份:2007
- 资助金额:
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7920844 - 财政年份:
- 资助金额:
$ 30.5万 - 项目类别:
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- 批准号:
8318786 - 财政年份:
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$ 30.5万 - 项目类别:
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项目 4:精神分裂症患者白质进展的脆弱性
- 批准号:
7684154 - 财政年份:
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