RHO-KINASE IN PATIENTS WITH ATHEROSCLEROSIS: EFFECTS OF STATINS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究的目的是研究FDA批准的医生常用的降胆固醇药物阿托伐他汀(立普妥)和瑞舒伐他汀(Crestor)对血小板、白细胞和动脉血流调节的影响。这一点很重要，因为我们正在寻找更有效地预防动脉粥样硬化和心脏病的方法。许多研究表明，这些药物在消炎和稳定斑块方面有效。我们有兴趣更好地了解这些药物对炎症的影响以及它们的作用机制。这是一项由调查人员发起的研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the study is to investigate the effects of atorvastatin (Lipitor) and rosuvastatin (Crestor), FDA approved drugs commonly prescribed by doctors to lower cholesterol, on certain function of platelets, white blood cells, and blood flow regulations by arteries. This is important because we are looking at ways to more effectively prevent atherosclerosis and heart disease. Many studies have demonstrated that these drugs are effective at reducing inflammation and stabilizing plaques. We are interested in better understanding the effects of these medicines on inflammation and the mechanism by which they act. This is an investigator initiated study.