CLINICAL TRIAL: METABOLIC EFFECTS OF SHORT-TERM WALNUT CONSUMPTION IN METABOLIC

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 广泛的流行病学证据表明，食用坚果可降低心血管疾病风险(CVD)和心血管疾病结局。坚果有一些相似的属性，但在镁、L精氨酸、欧米伽-3和其他脂肪成分上有所不同。核桃具有最佳的营养含量，对健康有积极的影响。核桃已被证明对血脂和血管反应性有良好的影响，但这些作用本身并不能解释在观察性研究中观察到的积极的健康影响。此外，核桃对代谢综合征的整体影响从未被研究过。到目前为止，核桃对炎症生物标记物、体重和胰岛素敏感性的影响机制尚不清楚。核桃包括许多潜在有益的微量营养素和植物化学物质，在这项研究中，我们建议检查核桃的影响，而不是大量营养素的含量。我们计划进行一项安慰剂对照的交叉研究，深入研究食用核桃对患有代谢综合征的男性和女性的短期影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Extensive epidemiologic evidence suggests that nut consumption decreases cardiovascular disease risk (CVD) and CVD outcomes. Tree nuts have some similar attributes, but differ in their magnesium, L-arginine, omega-three and other fat fractions. Walnuts have an optimal nutrient content to exert positive health effects. Walnuts have been shown to have a favorable effect on lipid profile and vascular reactivity but these effects alone do not explain the positive health effects observed in observational studies. In addition, the effect of walnuts on the metabolic syndrome as a whole has never been studied. To date the mechanisms of the effects of walnuts on inflammatory biomarkers, body weight and insulin sensitivity remain unknown. Walnuts include many potentially beneficial micronutrients and phytochemicals and in this study we propose to examine the effects of walnuts independent of macronutrient content. We plan to perform a placebo controlled cross-over study to examine in depth the short-term effects of walnut consumption in men and women with the metabolic syndrome.