CLINICAL TRIAL: METABOLIC EFFECTS OF SHORT-TERM WALNUT CONSUMPTION IN METABOLIC

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 广泛的流行病学证据表明，坚果消费降低心血管疾病风险（CVD）和CVD结果。树坚果有一些类似的属性，但不同的镁，L-精氨酸，ω-3和其他脂肪分数。 核桃具有最佳的营养成分，可以发挥积极的健康作用。核桃已被证明对血脂和血管反应性有良好的影响，但这些影响本身并不能解释观察性研究中观察到的积极健康影响。此外，核桃对整个代谢综合征的影响从未被研究过。到目前为止，核桃对炎症生物标志物、体重和胰岛素敏感性的影响机制仍然未知。核桃包括许多潜在的有益微量营养素和植物化学物质，在这项研究中，我们建议检查核桃的影响独立的常量营养素含量。我们计划进行一项安慰剂对照的交叉研究，以深入研究代谢综合征患者食用核桃的短期影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Extensive epidemiologic evidence suggests that nut consumption decreases cardiovascular disease risk (CVD) and CVD outcomes. Tree nuts have some similar attributes, but differ in their magnesium, L-arginine, omega-three and other fat fractions. Walnuts have an optimal nutrient content to exert positive health effects. Walnuts have been shown to have a favorable effect on lipid profile and vascular reactivity but these effects alone do not explain the positive health effects observed in observational studies. In addition, the effect of walnuts on the metabolic syndrome as a whole has never been studied. To date the mechanisms of the effects of walnuts on inflammatory biomarkers, body weight and insulin sensitivity remain unknown. Walnuts include many potentially beneficial micronutrients and phytochemicals and in this study we propose to examine the effects of walnuts independent of macronutrient content. We plan to perform a placebo controlled cross-over study to examine in depth the short-term effects of walnut consumption in men and women with the metabolic syndrome.