FOCAL DYSTONIA: GENOTYPE-PHENOTYPE CORRELATION

局灶性肌张力障碍：基因型与表型的相关性

• 批准号: 7731292
• 负责人: NUTAN SHARMA
• 金额: $ 0.15万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731292
• 关键词: Botulinum Toxins; Brain imaging; Clinical; Computer Retrieval of Information on Scientific Projects Database; Dystonia; Enrollment; Focal Dystonias; Functional disorder; Funding; Genes; Genetic Polymorphism; Genotype; Grant; Injection of therapeutic agent; Institution; Measures; Participant; Pathogenesis; Phenotype; Purpose; Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to investigate the role of specific polymorphisms in genes associated with the pathogenesis or pathophysiology of dystonia on the phenotype of focal dystonias, as measured by clinical exam, brain imaging studies and response to botulinum toxin injections. Anticipated enrollment is 360 participants: 160 participants who have focal dystonia and 200 healthy control participants.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究的目的是通过临床检查、脑成像检查和对肉毒毒素注射的反应，研究与肌张力障碍的发病机制或病理生理学相关的基因的特定多态性对局灶性肌张力障碍表型的影响。预计有360名参与者：160名患有局灶性肌张力障碍的参与者和200名健康对照参与者。