Quantum-Enabled Brain Imaging: A Pathway to Clinical Utility

量子脑成像:临床应用的途径

基本信息

  • 批准号:
    10083773
  • 负责人:
  • 金额:
    $ 14.95万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Small Business Research Initiative
  • 财政年份:
    2023
  • 资助国家:
    英国
  • 起止时间:
    2023 至 无数据
  • 项目状态:
    已结题

项目摘要

Our aim is to harness the potential of quantum technology in healthcare, by introducing a new type of scanner which has the potential to significantly impact human brain health.The human brain, and the disorders that affect it, represent an enormous challenge for 21st century healthcare. From diseases that strike in childhood, like epilepsy, to problems associated with old age, like dementia; brain health disorders are extremely debilitating, they devastate families, and they cost the UK over £100 billion per year.Brain scanners, like MRI, have had an enormous impact on our ability to manage all sorts of disorders. However, most scanners are designed to take pictures of what the brain looks like, and in many disorders it looks normal. Instead, symptoms relate to abnormalities in brain function i.e. what brain cells actually do. There is therefore a pressing need for a new generation of scanners that can accurately and robustly measure brain activity.We have pioneered the use of quantum technology in this field. Briefly, quantum sensors use the fundamental properties of atoms to measure things in the real world that we know exist, but we cannot see; like gravity, or magnetic fields. We know that brain cells communicate with each other via flow of small electrical currents, and those currents generate magnetic fields which pass through the skull and exist outside the head. We cannot see them, but we can use quantum sensors to detect them and, in this way, measure brain activity. We already know these measurements are useful; in epilepsy we can pinpoint brain regions responsible for seizures; in concussion we can see how head injury alters communication between different brain areas, and in dementia we can see how brain activity "slows down" offering a means for early diagnosis. Our challenge is now to translate this significant potential into a useful technology for healthcare providers.In Phase 1 of this project, we will partner with world leading clinicians to work out where our scanner could have the biggest impact, and how we should change it to deliver that impact. The output will be a set of requirements for a machine. In Phase 2 we will build this machine -- solving all the technical requirements emerging from Phase 1\. We will deploy this machine in a trial which will prove that quantum technology can help solve some of the most pressing problems in human brain health.
我们的目标是通过引入一种新型扫描仪,利用量子技术在医疗保健领域的潜力,这种扫描仪有可能对人类大脑健康产生重大影响。人类的大脑,以及影响它的疾病,是21世纪医疗保健面临的巨大挑战。从童年发作的疾病,如癫痫,到老年相关的问题,如痴呆;大脑健康障碍非常使人衰弱,它们摧毁了家庭,每年在英国造成的损失超过1000亿英镑。脑部扫描仪,比如核磁共振成像,对我们治疗各种疾病的能力产生了巨大的影响。然而,大多数扫描仪的设计目的是拍摄大脑的样子,在许多疾病中,它看起来很正常。相反,症状与大脑功能异常有关,即脑细胞的实际功能。因此,迫切需要一种新一代的扫描仪,能够准确而有力地测量大脑活动。我们在这一领域率先使用了量子技术。简而言之,量子传感器利用原子的基本特性来测量现实世界中我们知道存在、但我们看不见的事物;比如重力或磁场。我们知道脑细胞通过小电流相互交流,这些电流产生的磁场穿过头骨,存在于头部之外。我们无法看到它们,但我们可以用量子传感器来探测它们,并通过这种方式测量大脑活动。我们已经知道这些测量是有用的;在癫痫中,我们可以精确定位导致癫痫发作的大脑区域;在脑震荡中,我们可以看到头部损伤如何改变不同大脑区域之间的交流,在痴呆症中,我们可以看到大脑活动如何“减慢”,这为早期诊断提供了一种手段。我们现在面临的挑战是将这一巨大潜力转化为对医疗保健提供者有用的技术。在这个项目的第一阶段,我们将与世界领先的临床医生合作,找出我们的扫描仪可以在哪里产生最大的影响,以及我们应该如何改变它来实现这种影响。输出将是机器的一组需求。在第二阶段,我们将建造这台机器——解决第一阶段出现的所有技术要求。我们将在试验中部署这台机器,以证明量子技术可以帮助解决人类大脑健康中一些最紧迫的问题。

项目成果

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其他文献

Internet-administered, low-intensity cognitive behavioral therapy for parents of children treated for cancer: A feasibility trial (ENGAGE).
针对癌症儿童父母的互联网管理、低强度认知行为疗法:可行性试验 (ENGAGE)。
  • DOI:
    10.1002/cam4.5377
  • 发表时间:
    2023-03
  • 期刊:
  • 影响因子:
    4
  • 作者:
  • 通讯作者:
Differences in child and adolescent exposure to unhealthy food and beverage advertising on television in a self-regulatory environment.
在自我监管的环境中,儿童和青少年在电视上接触不健康食品和饮料广告的情况存在差异。
  • DOI:
    10.1186/s12889-023-15027-w
  • 发表时间:
    2023-03-23
  • 期刊:
  • 影响因子:
    4.5
  • 作者:
  • 通讯作者:
The association between rheumatoid arthritis and reduced estimated cardiorespiratory fitness is mediated by physical symptoms and negative emotions: a cross-sectional study.
类风湿性关节炎与估计心肺健康降低之间的关联是由身体症状和负面情绪介导的:一项横断面研究。
  • DOI:
    10.1007/s10067-023-06584-x
  • 发表时间:
    2023-07
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
  • 通讯作者:
ElasticBLAST: accelerating sequence search via cloud computing.
ElasticBLAST:通过云计算加速序列搜索。
  • DOI:
    10.1186/s12859-023-05245-9
  • 发表时间:
    2023-03-26
  • 期刊:
  • 影响因子:
    3
  • 作者:
  • 通讯作者:
Amplified EQCM-D detection of extracellular vesicles using 2D gold nanostructured arrays fabricated by block copolymer self-assembly.
使用通过嵌段共聚物自组装制造的 2D 金纳米结构阵列放大 EQCM-D 检测细胞外囊泡。
  • DOI:
    10.1039/d2nh00424k
  • 发表时间:
    2023-03-27
  • 期刊:
  • 影响因子:
    9.7
  • 作者:
  • 通讯作者:

的其他文献

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{{ truncateString('', 18)}}的其他基金

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用于实时测量循环生物标志物的植入式生物传感器微系统
  • 批准号:
    2901954
  • 财政年份:
    2028
  • 资助金额:
    $ 14.95万
  • 项目类别:
    Studentship
Exploiting the polysaccharide breakdown capacity of the human gut microbiome to develop environmentally sustainable dishwashing solutions
利用人类肠道微生物群的多糖分解能力来开发环境可持续的洗碗解决方案
  • 批准号:
    2896097
  • 财政年份:
    2027
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    $ 14.95万
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    Studentship
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  • 财政年份:
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    $ 14.95万
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    Studentship
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严重空间天气事件对核电和保障监督的恢复力的可能性和影响。
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    2908918
  • 财政年份:
    2027
  • 资助金额:
    $ 14.95万
  • 项目类别:
    Studentship
Proton, alpha and gamma irradiation assisted stress corrosion cracking: understanding the fuel-stainless steel interface
质子、α 和 γ 辐照辅助应力腐蚀开裂:了解燃料-不锈钢界面
  • 批准号:
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  • 财政年份:
    2027
  • 资助金额:
    $ 14.95万
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Field Assisted Sintering of Nuclear Fuel Simulants
核燃料模拟物的现场辅助烧结
  • 批准号:
    2908917
  • 财政年份:
    2027
  • 资助金额:
    $ 14.95万
  • 项目类别:
    Studentship
Assessment of new fatigue capable titanium alloys for aerospace applications
评估用于航空航天应用的新型抗疲劳钛合金
  • 批准号:
    2879438
  • 财政年份:
    2027
  • 资助金额:
    $ 14.95万
  • 项目类别:
    Studentship
Developing a 3D printed skin model using a Dextran - Collagen hydrogel to analyse the cellular and epigenetic effects of interleukin-17 inhibitors in
使用右旋糖酐-胶原蛋白水凝胶开发 3D 打印皮肤模型,以分析白细胞介素 17 抑制剂的细胞和表观遗传效应
  • 批准号:
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  • 财政年份:
    2027
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CDT year 1 so TBC in Oct 2024
CDT 第 1 年,预计 2024 年 10 月
  • 批准号:
    2879865
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    2027
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Understanding the interplay between the gut microbiome, behavior and urbanisation in wild birds
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  • 批准号:
    2876993
  • 财政年份:
    2027
  • 资助金额:
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