Relationships between Skin Pigmentation, Vitamin D and Blood Pressure

皮肤色素沉着、维生素 D 和血压之间的关系

• 批准号: 7772803
• 负责人: Flojaune Christina Griffin
• 金额: $ 5.77万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7772803
• 关键词: Academy; Accounting; Address; African American; Age; Age Factors; Aging; Behavioral; Biological; Biological Assay; Biological Factors; Blood Pressure; Body measure procedure; Calcifediol; Cardiovascular system; Categories; Caucasians; Caucasoid Race; Chronic Disease; Classification; Cohort Studies; Color; Communities; Cross-Sectional Studies; Cutaneous; Data; Databases; Diastolic blood pressure; Diet Habits; Dietary Supplementation; Dietary intake; Discrimination; Disease; Educational Status; Elements; Epidemiologic Studies; Ethnic Origin; Ethnic group; Etiology; Event; Exclusion; Exposure to; Food; Frequencies; Funding; Geographic Locations; Geography; Goals; Health; Health Policy; Health Status; Human; Hypertension; Incidence; Individual; Inherited; Intake; Intervention; Interview; Link; Literature; Longitudinal Studies; Measurement; Measures; Melanins; Michigan; Outcome; Patient Self-Report; Persons; Play; Population; Population Group; Positioning Attribute; Prevalence; Production; Proxy; Public Health; Race; Recording of previous events; Recruitment Activity; Regulation; Renin-Angiotensin System; Reporting; Research; Research Personnel; Resources; Risk; Risk Factors; Role; Sampling; Seasons; Secure; Serum; Site; Skin; Skin Pigmentation; Societies; Socioeconomic Status; Source; Sun Exposure; Sunlight; Testing; Time; UV Radiation Exposure; United States; United States National Center for Health Statistics; Variant; Vitamin D; Vitamin Deficiency; Woman; Women' s Health; Writing; absorption; age effect; base; blood pressure regulation; burden of illness; caucasian American; contextual factors; dietary supplements; disorder risk; experience; geographically distant; health disparity; high risk; indexing; longitudinal analysis; mortality; public health relevance; racial and ethnic; racism; repository; residence; sex; skin color; theories; trend; ultraviolet

DESCRIPTION (provided by applicant): The goal of this study is to characterize the effect of skin pigmentation on serum 25- hydroxycholecalciferol (vitamin D) levels, and, in turn, ascertain their association with blood pressure among women as they age. This doctoral research will test hypothesized relationships of skin color and vitamin D with blood pressure using existing data, repository resources, and newly-acquired data from the Study of Women's Health Across the Nation (SWAN). Literature suggests that vitamin D regulates the renin-angiotensin system and, by extension, blood pressure. Skin melanin content determines the amount of Vitamin D conversion via ultraviolet blue. Persons geographically distant from the equator seasonally lack ultraviolet-blue for adequate vitamin D synthesis, which compounds the decline in vitamin D production and absorption with age. These findings form the basis for the hypothesis that a missing link in the racial disparity in blood pressure is that many African Americans, who largely have darker skin than whites, obtain insufficient sunlight due to geographical location and limited outdoor exposure which, leads to inadequate vitamin D for healthy regulation of blood pressure. This is compounded by the effects of aging. The study will be implemented in SWAN, an ongoing multi-ethnic, multi-site longitudinal community-based study of women (aged 42-52 at baseline) recruited at seven United States sites, now in its 13th year. This study will use Michigan site data where the sample includes 218 white and 325 black women. Available resources include blood pressures, food frequency, dietary supplement history, and serum samples available to evaluate vitamin D. Interview-based measures of body exposure to sunlight and reflectometer-determined skin coloration will be ascertained for this doctoral research. Repeated measures analysis will be used to address within-subject correlations. Understanding the intersection of skin color, behavioral factors and chronic disease risk is important in addressing underlying causes of race/ethnic disparities in blood pressure. PUBLIC HEALTH RELEVANCE: This study will combine blood pressures, food frequency, dietary supplement history from existing data, serum samples to assay vitamin D from repository resources, and newly-acquired skin color data from the longitudinal, multi-ethnic Study of Women's Health Across the Nation (SWAN) to characterize the effect of skin pigmentation on serum 25-hydroxycholecalciferol (vitamin D) and blood pressure among women as they age.

描述（由申请人提供）：本研究的目的是描述皮肤色素沉着对血清25-羟基胆钙化醇（维生素D）水平的影响，并反过来确定其与女性血压的相关性。这项博士研究将测试肤色和维生素D与血压的假设关系，使用现有数据，存储库资源和新获得的数据来自全国妇女健康研究（SWAN）。文献表明，维生素D调节肾素-血管紧张素系统，进而调节血压。皮肤黑色素含量决定了维生素D通过紫外线蓝的转化量。地理上远离赤道的人季节性地缺乏足够的维生素D合成所需的紫外线蓝，这使得维生素D的产生和吸收随着年龄的增长而下降。这些发现构成了以下假设的基础，即血压种族差异的一个缺失环节是许多非洲裔美国人，他们的皮肤比白人深，由于地理位置和有限的户外暴露而获得的阳光不足，导致维生素D不足，无法健康调节血压。这是由老化的影响加剧。该研究将在SWAN中实施，SWAN是一项正在进行的多种族、多地点、以社区为基础的纵向研究，在美国7个地点招募了42-52岁的妇女，目前已进入第13个年头。本研究将使用密歇根州的研究中心数据，其中样本包括218名白色和325名黑人女性。可用的资源包括血压、食物频率、膳食补充剂历史和可用于评估维生素D的血清样本。这项博士研究将确定基于采访的身体暴露于阳光和反射仪确定的皮肤颜色的措施。重复测量分析将用于解决受试者内相关性。了解肤色，行为因素和慢性疾病风险的交叉点对于解决血压种族/民族差异的根本原因非常重要。 公共卫生关系：这项研究将结合联合收割机血压，食物频率，现有数据的膳食补充剂历史，血清样本，以测定储存库资源中的维生素D，和新获得的肤色数据，从纵向，多种族的妇女健康全国研究（SWAN），以表征皮肤色素沉着对血清25-羟基胆钙化醇（维生素D）和血压的影响，随着年龄的增长，妇女。