Relationships between Skin Pigmentation, Vitamin D and Blood Pressure

描述(申请人提供)：这项研究的目标是确定皮肤色素沉着对血清25-羟基胆钙素(维生素D)水平的影响，并进而确定它们与女性随着年龄增长的血压之间的关系。这项博士研究将利用现有数据、资料库资源和从全国妇女健康研究(SWAN)获得的新数据，测试肤色和维生素D与血压的假设关系。文献表明，维生素D调节肾素-血管紧张素系统，进而调节血压。皮肤黑色素含量决定了维生素D通过紫外线蓝的转换量。远离赤道的人季节性地缺乏足够的维生素D合成所需的紫外线蓝，这加剧了维生素D的产生和吸收随着年龄的增长而下降。这些发现构成了一种假设的基础，即血压种族差异中缺失的一环是许多非裔美国人由于地理位置和有限的户外暴露而获得的阳光不足，导致维他命D不足，无法健康地调节血压。老化的影响更是雪上加霜。这项研究将在SWAN进行，这是一项正在进行的多族裔、多地点、以社区为基础的纵向研究，对象是在美国七个地点招募的妇女(基线年龄为42-52岁)，目前已进入第13个年头。这项研究将使用密歇根州的现场数据，样本包括218名白人女性和325名黑人女性。可用的资源包括血压、食物频率、膳食补充剂历史和可用于评估维生素D的血清样本。这项博士研究将确定基于访谈的身体暴露在阳光下的测量方法和反射仪确定的皮肤颜色。重复测量分析将被用来解决受试者内部的相关性。了解肤色、行为因素和慢性病风险的交集对于解决种族/民族血压差异的根本原因非常重要。 公共卫生相关性：这项研究将结合现有数据中的血压、食物频率、膳食补充剂历史、从资料库资源中检测维生素D的血清样本，以及从纵向、多种族全国妇女健康研究(SWAN)中新获得的肤色数据，来表征皮肤色素沉着对女性随着年龄增长而对血清25-羟基胆钙醇(维生素D)和血压的影响。

DESCRIPTION (provided by applicant): The goal of this study is to characterize the effect of skin pigmentation on serum 25- hydroxycholecalciferol (vitamin D) levels, and, in turn, ascertain their association with blood pressure among women as they age. This doctoral research will test hypothesized relationships of skin color and vitamin D with blood pressure using existing data, repository resources, and newly-acquired data from the Study of Women's Health Across the Nation (SWAN). Literature suggests that vitamin D regulates the renin-angiotensin system and, by extension, blood pressure. Skin melanin content determines the amount of Vitamin D conversion via ultraviolet blue. Persons geographically distant from the equator seasonally lack ultraviolet-blue for adequate vitamin D synthesis, which compounds the decline in vitamin D production and absorption with age. These findings form the basis for the hypothesis that a missing link in the racial disparity in blood pressure is that many African Americans, who largely have darker skin than whites, obtain insufficient sunlight due to geographical location and limited outdoor exposure which, leads to inadequate vitamin D for healthy regulation of blood pressure. This is compounded by the effects of aging. The study will be implemented in SWAN, an ongoing multi-ethnic, multi-site longitudinal community-based study of women (aged 42-52 at baseline) recruited at seven United States sites, now in its 13th year. This study will use Michigan site data where the sample includes 218 white and 325 black women. Available resources include blood pressures, food frequency, dietary supplement history, and serum samples available to evaluate vitamin D. Interview-based measures of body exposure to sunlight and reflectometer-determined skin coloration will be ascertained for this doctoral research. Repeated measures analysis will be used to address within-subject correlations. Understanding the intersection of skin color, behavioral factors and chronic disease risk is important in addressing underlying causes of race/ethnic disparities in blood pressure. PUBLIC HEALTH RELEVANCE: This study will combine blood pressures, food frequency, dietary supplement history from existing data, serum samples to assay vitamin D from repository resources, and newly-acquired skin color data from the longitudinal, multi-ethnic Study of Women's Health Across the Nation (SWAN) to characterize the effect of skin pigmentation on serum 25-hydroxycholecalciferol (vitamin D) and blood pressure among women as they age.