Exercise Stress Cardiac Magnetic Resonance

运动压力心脏磁共振

• 批准号: 7745974
• 负责人: Orlando Paul Simonetti
• 金额: $ 37.01万
• 依托单位: EXCMR, LTD
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-25 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7745974
• 关键词: Achievement; Acoustics; Algorithms; American; Body Weight; Cardiac; Cardiovascular Diseases; Cardiovascular system; Computer software; Coronary Arteriosclerosis; Defect; Detection; Development; Diagnosis; Diagnostic; Diagnostic tests; Disease; Early Diagnosis; Echocardiography; Electrocardiogram; Engineering; Environment; Equipment; Evaluation; Event; Exercise; Exercise stress test; Exertion; Fatigue; Goals; Guidelines; Heart; Heart Diseases; Heart Rate; Image; Imaging Techniques; Investigation; Ionizing radiation; Ischemia; Lead; Lung diseases; Magnetic Resonance; Magnetic Resonance Imaging; Morphologic artifacts; Motion; Myocardial perfusion; Noise; Nuclear; Obesity; Patients; Performance; Perfusion; Phase; Photons; Physiologic pulse; Protocols documentation; Radiation; Research; Resolution; Safety; Sales; Slice; Societies; Staging; Stress; Stress Tests; System; Technology; Testing; Time; Ultrasonography; Validation; attenuation; base; cohort; commercialization; design; design and construction; effective therapy; heart imaging; image processing; imaging modality; improved; innovation; insight; magnetic field; meetings; new technology; older patient; prototype; public health relevance; response; rib bone structure; soft tissue; technology development; tomography; tool; treatment strategy

DESCRIPTION (provided by applicant): Exercise stress testing with imaging is widely used to detect heart disease, but current stress imaging systems suffer from false positives that may lead to unnecessary invasive testing, and false negatives that may miss disease detection until a serious event occurs. Thus, consistently accurate stress imaging remains an important target for technology development. Cardiac magnetic resonance (CMR) provides superior imaging of the heart without ionizing radiation, but technology has not been developed to allow CMR immediately following maximal exercise stress. A revolutionary change to the current landscape of cardiac stress testing could result by adding exercise testing to CMR, thus establishing a "one-stop" imaging modality for accurately assessing heart disease in a single examination. This project focuses on the research and commercialization of an MRI-based system for enhanced exercise stress testing for patients with suspected cardiovascular disease. The key enabling technology is an innovative non-ferromagnetic treadmill that enables convenient placement immediately adjacent to the MRI machine. Standard treadmills would have to be placed far from the MRI magnet outside the MRI room, leading to critical delays between exercise and image acquisition, as well as safety concerns for compromised patients who must, in a fatigued and stressed state, traverse the distance from the treadmill to the MRI table. Our innovative design will overcome these problems and furthermore, enable image acquisition immediately post-exercise. The resulting high resolution images are expected to be superior to nuclear single photon emission tomography (SPECT) and ultrasound, and clearly show stress wall motion, stress perfusion, and viability. The design, implementation, and feasibility testing of this new technology by a coordinated team of engineers and clinicians (Phase I), followed by a multi-center investigation showing improved accuracy over existing stress imaging methods (Phase II) is expected to lead to a sizeable commercial opportunity for the manufacture and sale of MRI stress testing equipment. Phase I of this project will be accomplished by meeting the following specific aims: " Design and construct an MRI-compatible treadmill capable of performing the standard Bruce stress test protocol immediately adjacent to MRI systems up to 3T field strength. " Demonstrate feasibility of treadmill exercise stress MRI of cardiac function and perfusion in patients with suspected coronary artery disease. Successful achievement of the aims of this Phase I project will lead to Phase II multi-center validation of this new stress imaging modality, including direct comparison with nuclear SPECT. The combination of exercise stress testing and CMR could greatly enhance our understanding of CAD, and enable earlier diagnosis and more effective treatment strategies. PUBLIC HEALTH RELEVANCE: Exercise testing and magnetic resonance imaging (MRI) have independently shown tremendous utility in the diagnosis and treatment of heart disease. Exercise stress testing provides important information about the heart's response to physical exertion, and MRI is a non-invasive imaging method that has many advantages over other imaging techniques. This project develops and evaluates the new equipment needed to combine exercise testing with MRI, and is expected to result in an improved test for the diagnosis of heart disease.

描述(申请人提供)：运动负荷试验和成像被广泛用于检测心脏病，但目前的负荷成像系统存在可能导致不必要的侵入性测试的假阳性，以及可能在严重事件发生之前错过疾病检测的假阴性。因此，始终准确的应力成像仍然是技术发展的重要目标。心脏磁共振(CMR)在没有电离辐射的情况下提供了卓越的心脏成像，但还没有开发出在最大运动应激后立即进行CMR的技术。通过将运动测试添加到CMR中，可以对目前的心脏压力测试产生革命性的变化，从而建立一种在一次检查中准确评估心脏病的“一站式”成像模式。该项目的重点是研究和商业化一种基于磁共振成像的系统，用于为疑似心血管疾病患者加强运动负荷测试。关键的支持技术是一种创新的非铁磁跑步机，使其能够方便地放置在紧挨着核磁共振机器的位置。标准的跑步机必须放在远离核磁共振成像磁铁的地方，这会导致锻炼和图像获取之间的严重延误，并对受到影响的患者产生安全担忧，这些患者必须在疲惫和紧张的状态下，从跑步机到核磁共振检查台之间的距离。我们的创新设计将克服这些问题，此外，还可以在运动后立即获取图像。由此得到的高分辨率图像有望优于核单光子发射断层扫描(SPECT)和超声，并清楚地显示应力壁运动、应力灌流和生存能力。由工程师和临床医生组成的协调团队对这项新技术进行设计、实施和可行性测试(第一阶段)，然后进行一项多中心调查，显示出比现有应力成像方法更准确的结果(第二阶段)，预计将为MRI压力测试设备的制造和销售带来巨大的商业机会。该项目的第一阶段将通过满足以下具体目标来完成：“设计和建造一台与MRI兼容的跑步机，能够执行标准的Bruce负荷测试协议，紧邻高达3T场强的MRI系统。”对可疑冠心病患者进行跑台运动负荷核磁共振心功能和血流灌注检测的可行性。这一第一阶段项目目标的成功实现将导致这一新的应力成像模式的第二阶段多中心验证，包括与核SPECT的直接比较。运动负荷试验和CMR的结合可以极大地提高我们对CAD的认识，使我们能够更早地诊断和更有效的治疗策略。与公众健康相关：运动测试和核磁共振成像(MRI)在心脏病的诊断和治疗中显示出巨大的实用价值。运动负荷测试提供了有关心脏对体力消耗反应的重要信息，而磁共振成像是一种非侵入性成像方法，与其他成像技术相比具有许多优势。该项目开发和评估了将运动测试与核磁共振相结合所需的新设备，并有望改进心脏病诊断的测试。

项目成果

Real-time cine and myocardial perfusion with treadmill exercise stress cardiovascular magnetic resonance in patients referred for stress SPECT.

• DOI: 10.1186/1532-429x-12-41
• 发表时间: 2010-07-12
• 期刊: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
• 作者: Raman SV;Dickerson JA;Jekic M;Foster EL;Pennell ML;McCarthy B;Simonetti OP
• 通讯作者: Simonetti OP