Ultra-wide Field-of-View Endoscope for White Light and Narrow Band Imaging

用于白光和窄带成像的超宽视场内窥镜

• 批准号: 7748042
• 负责人: Haibo Liu
• 金额: $ 6.5万
• 依托单位: INTERSCIENCE, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-04 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7748042
• 关键词: Address; Advanced Development; Algorithms; Area; Arts; Blood capillaries; Caliber; Characteristics; Clinical; Colonoscopy; Computer software; Cystoscopy; Development; Diagnosis; Diagnostic Procedure; Distal; Early Diagnosis; Electronics; Endoscopes; Evaluation; Fiber; Gastroenterology; Government; Hand; Image; Imagery; Imaging technology; Individual; Laparoscopy; Laryngoscopy; Left; Legal patent; Lesion; Light; Lighting; Malignant Neoplasms; Market Research; Medical; Mucous Membrane; Optics; Patients; Persons; Phase; Procedures; Resolution; Sensitivity and Specificity; Software Design; Solid; Source; Specificity; Surface; System; Technology; Testing; Time; Trauma; Ureteroscopy; Vendor; Work; base; capillary; design; flexibility; image processing; image registration; improved; innovation; minimally invasive; optical imaging; optical sensor; public health relevance; sensor

DESCRIPTION (provided by applicant): Endoscopic visualization is of primary importance for minimally invasive procedures. However, known limitations of current endoscopic imaging technology include the limited field-of-view, and unsatisfactory specificity and sensitivity. InterScience hereby proposes an omnidirectional endoscopic system with both white light and narrow band imaging capability, based on our patented and patent pending C-ViewTM optical technology, allowing a broad field-of-view up to 120 degrees about the optical axis and 360 degrees panoramically (3@ steradian solid angle). In addition to normal white light observation, the proposed system offers narrow band imaging function (illuminated with narrowed red, green, or blue bands of light), targeting to assist the early detection of minute lesions such as cancer and preoperative accurate diagnosis of diseased areas. It will also deliver enhanced images of characteristic changes of lesions and capillary vessels in the mucosal surface, and slight thickening of the mucosa as well as vessels deep in the mucosa - by controlling the wavelength of light used. The unprecedented wide field- of-view of the proposed endoscope would greatly improve imaging coverage and consistency without image registration, as well as increase the specificity and procedure thoroughness while minimizing procedure time and trauma to the patient induced by intra-procedural swapping of various beveled scopes. The Phase I efforts include imaging optics design, illumination design, preliminary electrical designs, image processing algorithm development, plus the studies and tests of some off-the-shelf components. PUBLIC HEALTH RELEVANCE: Project Narrative The endoscope with an unprecedented field-of-view (larger than a hemisphere), and white light and narrow band imaging functions will present much more specific information to clinicians for abnormalities diagnosis, and will be more advantageous to assist minimum invasive procedures than currently existing endoscopic systems.

描述（由申请人提供）：内镜可视化对微创手术至关重要。然而，目前已知的内窥镜成像技术的局限性包括视野有限，特异性和敏感性不理想。InterScience在此提出了一种全向内窥镜系统，基于我们的专利和正在申请专利的C-ViewTM光学技术，具有白光和窄带成像能力，可实现围绕光轴120度的宽视场和360度全景（3@立体角）。除了正常的白光观察外，该系统还提供窄带成像功能（用狭窄的红、绿、蓝光带照射），旨在帮助早期发现癌症等微小病变，并在术前准确诊断病变区域。它还可以通过控制所用光的波长，提供病变和粘膜表面毛细血管的特征性变化，粘膜的轻微增厚以及粘膜深处血管的增强图像。所提出的内窥镜史无前例的宽视场将大大提高图像的覆盖范围和一致性，而无需图像配准，并增加特异性和手术的彻底性，同时最大限度地减少手术时间和术中各种斜面镜交换对患者造成的创伤。第一阶段的工作包括成像光学设计、照明设计、初步电气设计、图像处理算法开发，以及一些现成组件的研究和测试。内窥镜具有前所未有的视野（大于一个半球），白光和窄带成像功能，将为临床医生提供更具体的异常诊断信息，并且比目前现有的内窥镜系统更有利于辅助微创手术。