STDY OF SIROLIMUS/RAPAMYCIN IN PTS W/ADVNCD PAH REFRACTORY TO CRNTLY AVAIL THRPY

西罗莫司/雷帕霉素在治疗 ADVNCD PAH 难治性 PTS 中的研究

• 批准号: 7719522
• 负责人: David B. Badesch
• 金额: $ 0.03万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719522
• 关键词: Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Disease; Funding; Future; Grant; Institution; Intervention; Numbers; Patients; Pilot Projects; Refractory; Research; Research Personnel; Resources; Safety; Sirolimus; Source; Staging; Testing; United States National Institutes of Health; improved; pulmonary arterial hypertension; trend

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This pilot study is being done to assess the safety of sirolimus in patients with severe, late-stage pulmonary arterial hypertension who are not improving despite maximal currently available therapy. This study will be testing a biomedical intervention (Sirolimus) that is new to patients with PAH in a small number of patients with advanced disease to assess safety and meaningful trends toward efficacy that would potentially support the future conduct of a larger single-center clinical trial.

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