CEREBRAL & NEUROCOGNITIVE FNCTN IN HIV-INFECTED PRSNS W/ADVNCD HRT DISZ ON HAART

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 艾滋病毒感染会导致大脑功能或大脑结构出现问题，例如大脑区域体积减少，以及精神功能和行为方面的问题。某些治疗艾滋病毒感染的药物可能有助于解决这些问题，但一些艾滋病毒携带者可能仍然会出现这些问题，特别是随着他们年龄的增长或感染艾滋病毒的时间较长。 这项研究的目的是了解随着时间的推移，艾滋病毒感染对大脑功能和结构的影响，以及对精神功能和行为的影响。这项研究的目的是确定哪些患者可能面临更大的脑部并发症风险，发现有助于确定哪些患者可能存在风险的因素或生物标记物，并了解治疗、CD4计数、病毒载量和其他免疫或病毒功能标记物的变化如何影响大脑。为了实现这些目标，我们将通过使用磁共振成像(MRI)对艾滋病毒感染者的大脑进行成像，来确定和比较不同大脑化学物质的数量和不同大脑区域的体积。我们还将把这些结果与神经学和神经心理学测试的结果进行比较，并与CD4计数、艾滋病毒和其他与免疫系统相关的蛋白质等因素的水平进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV infection can result in problems in brain function or brain structure such a decrease in the volume of a brain region and problems in mental function and behavior. Certain medications for HIV infection may help with these problems, but it is possible that some patients with HIV may still develop these problems especially as they become older or have had HIV for a long period of time. The purpose of this study is to understand the effects of HIV infection over time on brain function and structure in addition to mental function and behavior. The aims of the study are to identify which patients may be at greater risk for these brain complications, discover factors or "biomarkers" that will help determine which patients may be a risk and to understand how changes in treatment, CD4 count, viral load and other markers of immune or viral function affect the brain. To achieve these goals, we will determine and compare the amount of different brain chemicals and the volume of different brain regions by taking images of the brain using an MRI (magnetic resonance imaging) in HIV-infected people. We will also compare these results to those from neurological and neuropsychological tests and to levels of factors such as CD4 count, HIV and other proteins related to the immune system.