CEREBRAL & NEUROCOGNITIVE FNCTN IN HIV-INFECTED PRSNS W/ADVNCD HRT DISZ ON HAART

大脑

• 批准号: 7719523
• 负责人: THOMAS A CAMPBELL
• 金额: $ 0.41万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719523
• 关键词: Affect; Behavior; Biological Markers; Brain; Brain imaging; Brain region; CD4 Lymphocyte Count; Cerebrum; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Funding; Goals; Grant; HIV; HIV Infections; Immune system; Immunologic Markers; Institution; Magnetic Resonance Imaging; Neurocognitive; Neurologic; Neuropsychological Tests; Patients; Pharmaceutical Preparations; Proteins; Psyche structure; Purpose; Research; Research Personnel; Resources; Risk; Source; Structure; Time; United States National Institutes of Health; Viral Load result; Viral Physiology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV infection can result in problems in brain function or brain structure such a decrease in the volume of a brain region and problems in mental function and behavior. Certain medications for HIV infection may help with these problems, but it is possible that some patients with HIV may still develop these problems especially as they become older or have had HIV for a long period of time. The purpose of this study is to understand the effects of HIV infection over time on brain function and structure in addition to mental function and behavior. The aims of the study are to identify which patients may be at greater risk for these brain complications, discover factors or "biomarkers" that will help determine which patients may be a risk and to understand how changes in treatment, CD4 count, viral load and other markers of immune or viral function affect the brain. To achieve these goals, we will determine and compare the amount of different brain chemicals and the volume of different brain regions by taking images of the brain using an MRI (magnetic resonance imaging) in HIV-infected people. We will also compare these results to those from neurological and neuropsychological tests and to levels of factors such as CD4 count, HIV and other proteins related to the immune system.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 HIV 感染可导致大脑功能或大脑结构问题，例如大脑区域体积减少以及心理功能和行为问题。某些治疗艾滋病毒感染的药物可能有助于解决这些问题，但一些艾滋病毒感染者可能仍然会出现这些问题，特别是当他们变老或长期感染艾滋病毒时。 本研究的目的是了解随着时间的推移，除了心理功能和行为之外，艾滋病毒感染对大脑功能和结构的影响。该研究的目的是确定哪些患者可能面临这些大脑并发症的更高风险，发现有助于确定哪些患者可能存在风险的因素或“生物标志物”，并了解治疗、CD4计数、病毒载量和其他免疫或病毒功能标志物的变化如何影响大脑。为了实现这些目标，我们将通过使用 MRI（磁共振成像）拍摄 HIV 感染者的大脑图像来确定和比较不同大脑化学物质的数量以及不同大脑区域的体积。我们还将这些结果与神经学和神经心理学测试的结果以及 CD4 计数、HIV 和其他与免疫系统相关的蛋白质等因素的水平进行比较。