CEREBRAL & NEUROCOGNITIVE FNCTN IN HIV-INFECTED PRSNS W/ADVNCD HRT DISZ ON HAART

大脑

• 批准号: 7719523
• 负责人: THOMAS A CAMPBELL
• 金额: $ 0.41万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719523
• 关键词: Affect; Behavior; Biological Markers; Brain; Brain imaging; Brain region; CD4 Lymphocyte Count; Cerebrum; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Funding; Goals; Grant; HIV; HIV Infections; Immune system; Immunologic Markers; Institution; Magnetic Resonance Imaging; Neurocognitive; Neurologic; Neuropsychological Tests; Patients; Pharmaceutical Preparations; Proteins; Psyche structure; Purpose; Research; Research Personnel; Resources; Risk; Source; Structure; Time; United States National Institutes of Health; Viral Load result; Viral Physiology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV infection can result in problems in brain function or brain structure such a decrease in the volume of a brain region and problems in mental function and behavior. Certain medications for HIV infection may help with these problems, but it is possible that some patients with HIV may still develop these problems especially as they become older or have had HIV for a long period of time. The purpose of this study is to understand the effects of HIV infection over time on brain function and structure in addition to mental function and behavior. The aims of the study are to identify which patients may be at greater risk for these brain complications, discover factors or "biomarkers" that will help determine which patients may be a risk and to understand how changes in treatment, CD4 count, viral load and other markers of immune or viral function affect the brain. To achieve these goals, we will determine and compare the amount of different brain chemicals and the volume of different brain regions by taking images of the brain using an MRI (magnetic resonance imaging) in HIV-infected people. We will also compare these results to those from neurological and neuropsychological tests and to levels of factors such as CD4 count, HIV and other proteins related to the immune system.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 艾滋病毒感染会导致大脑功能或大脑结构的问题，因此大脑区域的体积减少以及心理功能和行为问题。某些艾滋病毒感染的药物可能有助于解决这些问题，但是某些艾滋病毒患者可能仍会出现这些问题，尤其是随着年龄的增长或长期患HIV。 这项研究的目的是了解除心理功能和行为外，随着时间的流逝，HIV感染对脑功能和结构的影响。该研究的目的是确定哪些患者可能会面临这些大脑并发症，发现因素或“生物标志物”的风险，这些因素或“生物标志物”将有助于确定哪些患者可能有风险，并了解治疗，CD4计数，病毒载荷，免疫或病毒功能的变化如何影响大脑。为了实现这些目标，我们将通过在HIV感染者中使用MRI（磁共振成像）拍摄大脑图像，从而确定和比较不同大脑化学物质的数量和不同大脑区域的体积。我们还将将这些结果与神经和神经心理学测试的结果以及与免疫系统相关的CD4计数，HIV和其他蛋白质等因素的水平进行比较。