CEREBRAL & NEUROCOGNITIVE FNCTN IN HIV-INFECTED PRSNS W/ADVNCD HRT DISZ ON HAART
大脑
基本信息
- 批准号:7719523
- 负责人:
- 金额:$ 0.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-04-01 至 2008-05-31
- 项目状态:已结题
- 来源:
- 关键词:AffectBehaviorBiological MarkersBrainBrain imagingBrain regionCD4 Lymphocyte CountCerebrumChemicalsComputer Retrieval of Information on Scientific Projects DatabaseFundingGoalsGrantHIVHIV InfectionsImmune systemImmunologic MarkersInstitutionMagnetic Resonance ImagingNeurocognitiveNeurologicNeuropsychological TestsPatientsPharmaceutical PreparationsProteinsPsyche structurePurposeResearchResearch PersonnelResourcesRiskSourceStructureTimeUnited States National Institutes of HealthViral Load resultViral Physiology
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
HIV infection can result in problems in brain function or brain structure such a decrease in the volume of a brain region and problems in mental function and behavior. Certain medications for HIV infection may help with these problems, but it is possible that some patients with HIV may still develop these problems especially as they become older or have had HIV for a long period of time.
The purpose of this study is to understand the effects of HIV infection over time on brain function and structure in addition to mental function and behavior. The aims of the study are to identify which patients may be at greater risk for these brain complications, discover factors or "biomarkers" that will help determine which patients may be a risk and to understand how changes in treatment, CD4 count, viral load and other markers of immune or viral function affect the brain. To achieve these goals, we will determine and compare the amount of different brain chemicals and the volume of different brain regions by taking images of the brain using an MRI (magnetic resonance imaging) in HIV-infected people. We will also compare these results to those from neurological and neuropsychological tests and to levels of factors such as CD4 count, HIV and other proteins related to the immune system.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
艾滋病毒感染可导致大脑功能或大脑结构的问题,如大脑区域体积的减少以及精神功能和行为的问题。某些治疗HIV感染的药物可能有助于解决这些问题,但一些HIV感染者可能仍然会出现这些问题,特别是当他们年龄较大或长期感染HIV时。
这项研究的目的是了解随着时间的推移,艾滋病毒感染对大脑功能和结构以及心理功能和行为的影响。该研究的目的是确定哪些患者可能面临更大的脑部并发症风险,发现有助于确定哪些患者可能存在风险的因素或“生物标志物”,并了解治疗,CD 4计数,病毒载量和其他免疫或病毒功能标志物的变化如何影响大脑。为了实现这些目标,我们将通过使用MRI(磁共振成像)对HIV感染者的大脑进行成像,来确定和比较不同大脑化学物质的数量和不同大脑区域的体积。我们还将这些结果与神经学和神经心理学测试的结果以及CD 4计数,HIV和其他与免疫系统相关的蛋白质等因素的水平进行比较。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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THOMAS A CAMPBELL其他文献
THOMAS A CAMPBELL的其他文献
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{{ truncateString('THOMAS A CAMPBELL', 18)}}的其他基金
ACTG A5211-SAFETY AND EFFICACY OF SCH 417690 IN HIV-INF, TRTMNT-EXP SUBJCTS
ACTG A5211-SCH 417690 在 HIV-INF、TRTMNT-EXP 受试者中的安全性和有效性
- 批准号:
7719470 - 财政年份:2008
- 资助金额:
$ 0.41万 - 项目类别:
ACTG 362-METAB,CARDIOVAS&NEUROLCOMPLICA'S IN SUBJ'S W/PAST CD4 CELL
ACTG 362-METAB,卡迪瓦斯
- 批准号:
7719416 - 财政年份:2008
- 资助金额:
$ 0.41万 - 项目类别:
ACTG A5095 -PROTEASE INHIBITOR-SPARING REGIMENS FOR THE INITIAL TREATMENT OF HIV
ACTG A5095 - HIV 初始治疗的蛋白酶抑制剂保留方案
- 批准号:
7719426 - 财政年份:2008
- 资助金额:
$ 0.41万 - 项目类别:
EVALOF EFFICACY OF ONCE/DAY PROTEASE INHBTR& ONCE/DAY NONNUCLEOSIDE REVERSE
每日一次蛋白酶 INHBTR 的功效评估
- 批准号:
7719467 - 财政年份:2008
- 资助金额:
$ 0.41万 - 项目类别:
ACTG A5001 - LONGITUDINAL LINKED RANDOMIZED TRIALS (ALLRT) PROTOCOL
ACTG A5001 - 纵向连锁随机试验 (ALLRT) 方案
- 批准号:
7719419 - 财政年份:2008
- 资助金额:
$ 0.41万 - 项目类别:
MEASURE CLEARANCE OF REPLICATION-COMPETENT HIV-1 IN RESTING MEMORY CD4+ CELLS
测量静息记忆 CD4 细胞中复制能力的 HIV-1 清除率
- 批准号:
7719441 - 财政年份:2008
- 资助金额:
$ 0.41万 - 项目类别:
ACTG A5164(V 20)-ANTIRETROVIRAL THERAPY FOR HIV-INFECTED ADULTS W/ACUTE OIS
ACTG A5164(V 20)-针对感染 HIV 并患有急性 OIS 的成人的抗逆转录病毒治疗
- 批准号:
7719463 - 财政年份:2008
- 资助金额:
$ 0.41万 - 项目类别:
ACTG A5146:IMPACT OF THERAPEUTIC DRUG MONITORING (TDM) ON VIROLOGIC RESPONSE
ACTG A5146:治疗药物监测 (TDM) 对病毒学反应的影响
- 批准号:
7719430 - 财政年份:2008
- 资助金额:
$ 0.41万 - 项目类别:
ACTG A5202 (VS 10): TRIAL OF OPEN-LABEL EFAVIRENZ OR ATAZANAVIR WITH RITONAVIR
ACTG A5202(VS 10):开放标签依非韦伦或阿扎那韦与利托那韦的试验
- 批准号:
7719505 - 财政年份:2008
- 资助金额:
$ 0.41万 - 项目类别:
ACTG A5030-VALGANCICLOVIR PRE-EMPTIVE THERAPY FOR CYTOMEGALOVIRUS (CMV) VIREMIA
ACTG A5030-缬更昔洛韦预防巨细胞病毒 (CMV) 病毒血症
- 批准号:
7719423 - 财政年份:2008
- 资助金额:
$ 0.41万 - 项目类别:
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