HIGH-COMPLEX-HIGH-REFINED-CHO MEALS, AND LOW-CHO MEALS ON ENDOTHELIAL FUNCTION

高复合、高精制膳食和低膳食对内皮功能的影响

• 批准号: 7718571
• 负责人: GLENN A GAESSER
• 金额: $ 11.38万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718571
• 关键词: Age; Analysis of Variance; Atherosclerosis; Attenuated; Carbohydrates; Cereals; Clinical; Complex; Computer Retrieval of Information on Scientific Projects Database; Computer software; Development; Diet; Endothelium; Fiber; Funding; Grant; Human; Impairment; Institution; Invasive; Link; Measures; Mediating; Nitric Oxide; Overweight; Participant; Research; Research Personnel; Resolution; Resources; Risk; Role; Source; Ultrasonography; United States National Institutes of Health; Vasodilator Agents; brachial artery; cardiovascular disorder risk; improved; in vivo Bioassay; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Flow-mediated dilation (FMD) of the brachial artery using high-resolution ultrasound is a well accepted non-invasive bioassay for in vivo endothelium-generated nitric oxide (NO) in humans. NO has been characterized as a potent vasodilator, but NO also has a considerable role in maintaining healthy endothelium and inhibiting key steps in the development, progression, and clinical manifestations of atherosclerosis. Because the postprandial state may be critical in the development of atherosclerosis, and because diets high in cereal fiber have been linked to reduced risk of cardiovascular disease, we hypothesize that a high-carbohydrate, high-fiber meal would acutely improve FMD. By contrast, we hypothesize that a low-carbohydrate meal will impair FMD, and that a high-carbohydrate, low-fiber meal will have no effect on FMD. We also hypothesize that the addition of a high-fiber breakfast cereal to the low-carbohydrate meal will attenuate the impairment of FMD observed after the low-carbohydrate meal. Brachial artery flow-mediated dilation (FMD) will be assessed before and at 2 h and 4 h after each of four breakfast meals (high-carbohydrate, high-fiber; high-carbohydrate, low-fiber; low-carbohydrate, low-fiber; low-carbohydrate, high-fiber) using high-resolution ultrasound and edge-detection software in 12 participants ages 8-17 who are overweight or at-risk for overweight, 12 participants ages 18-64, and 12 participants ages 65 and older. Analysis of variance with repeated measures will be used to assess differences in FMD in response to the meal challenges.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 使用高分辨率超声对肱动脉进行血流介导扩张 (FMD) 是一种广为接受的非侵入性生物测定方法，用于检测人体体内内皮生成的一氧化氮 (NO)。 NO 被认为是一种有效的血管扩张剂，但 NO 在维持健康的内皮和抑制动脉粥样硬化的发生、进展和临床表现的关键步骤方面也具有相当大的作用。 由于餐后状态可能对动脉粥样硬化的发展至关重要，而且富含谷物纤维的饮食与降低心血管疾病的风险有关，因此我们假设高碳水化合物、高纤维的膳食将显着改善 FMD。 相比之下，我们假设低碳水化合物膳食会损害 FMD，而高碳水化合物、低纤维膳食对 FMD 没有影响。 我们还假设，在低碳水化合物膳食中添加高纤维早餐谷物将减轻低碳水化合物膳食后观察到的口蹄疫损害。将使用高分辨率超声和边缘检测软件对 12 名 8-17 岁超重或有肥胖风险的参与者进行四顿早餐（高碳水化合物、高纤维；高碳水化合物、低纤维；低碳水化合物、低纤维；低碳水化合物、高纤维）之前、之后 2 小时和 4 小时的肱动脉血流介导扩张 (FMD) 评估。 超重，12名参与者年龄在18-64岁，12名参与者年龄在65岁及以上。 重复测量的方差分析将用于评估 FMD 应对膳食挑战的差异。