CLINICAL TRIAL: EFFECTS OF LOCAL GM-CSF IN-ADJUVANT ON DENDRITIC CELLS IN MELANO

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 通过加入细胞因子作为佐剂，可以提高针对黑色素瘤的疫苗效果。这项初步研究旨在分析GM-CSF佐剂对黑色素瘤患者皮肤和前哨淋巴结中树突状细胞(DC)的影响。目的是确定：(A)注射GM-CSF一周后是否出现最大的DC向真皮的渗透，(B)注射部位DC的增加由成熟和未成熟的DC组成，以及(C)引流注射部位的前哨免疫结节DC的增加主要由成熟DC组成。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Vaccination efficacy against melanoma may be improved by incorporating cytokines as adjuvants. This pilot study was designed to analyze the effects of GM-CSF in-adjuvant administration on dendritic cells (DC) in the skin and sentinel lymph nodes of melanoma patients. The objectives are to determine whether:(a) maximal DC infiltration into the dermis occurs one week following administration of GM-CSF, (b) an increase in DCs at the site of injection is comprised of mature and immature DC, and (c) an increase in DC in the sentinel immunized node draining the injection site is comprised mostly of mature DC.