D1, AT1 RECEPTORS IN HUMAN HYPERTENSION: SODIUM SENSITIVITY OF BLOOD PRESSURE

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 本研究的目的是确定盐敏感性和遗传变异之间是否存在关系。 某些遗传模式可能会导致肾脏摆脱膳食钠的能力发生变化，导致钠和水潴留，随后血压升高。将对多达3000人进行基因筛查，以确定具有某些基因谱的人。将邀请400名筛选的受试者参加两周的饮食，一周低盐和一周高盐，随机顺序。当受试者接受两周的不同盐饮食时，将进行血压测量、尿液和血液检查。血压从低盐饮食到高盐饮食的显著升高将表明盐敏感性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine if there is a relationship between salt sensitivity and genetic variations. Certain genetic patterns may result in a change in the ability of the kidney to get rid of dietary sodium, resulting in sodium and water retention and a subsequent rise in blood pressure. Genetic screening will be performed in up to 3000 people in order to identify those with certain gene profiles. Four hundred (400) of those screened will be invited to participate in two weeks of diets, one week of low salt and one week of high salt, in randomized order. Blood pressure measurements, urine and blood tests will be taken while subjects are on the two weeks of varied salt diets. A significant rise in blood pressure from low salt to high salt diets will indicate salt sensitivity.