IMPACT OF OBESITY AND PHYSICAL ACTIVITY ON ENDOMETRIAL CANCER GENESIS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 肥胖在美国正达到史诗般的比例，65%的人口被定义为超重（身体质量指数-BMI>25），30%也被定义为肥胖（BMI>30）。 肥胖与许多不良健康后果有关，包括心血管疾病、糖尿病和结肠癌、前列腺癌、胰腺癌、乳腺癌和子宫内膜癌（子宫内膜）。 子宫内膜癌是美国妇女中第四大常见癌症，预计2005年将影响40，000名妇女。 大约40%的子宫内膜癌可归因于肥胖，这被认为主要是由于通过雄激素转化为雌激素而增加脂肪细胞（脂肪细胞）中的雌激素产生。然而，并不是所有的肥胖妇女都会患上子宫内膜癌，这表明除了雌激素增加之外，其他因素也必须在恶性转化过程中发挥作用。 肥胖妇女的保护因素包括身体活动，但这种保护的确切机制仍然知之甚少。 关于超重和肥胖妇女的脂肪细胞衍生因子或体力活动水平的前瞻性数据很少。因此，本研究的目的是前瞻性地收集接受子宫切除术的超重和肥胖绝经后妇女的基线体力活动指标、基线体重指数、基线激素水平、血液/脂肪样本和子宫内膜样本。 收集后，我们将探索和确定患有和没有子宫内膜癌的女性在脂肪或血液生物标志物或体力活动水平方面的差异。 本研究的目的是更好地确定绝经后超重和肥胖妇女易患子宫内膜癌的危险因素，并确定与体力活动相关的任何保护因素。这项研究的最终目标是能够预测，并可能最终预防肥胖妇女子宫内膜癌的发展。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity in the United States is reaching epic proportions with 65% of the population being defined as overweight (body mass index-BMI>25) and 30% also qualifying as obese (BMI>30). Obesity is linked to numerous adverse health consequences including cardiovascular disease, diabetes and cancers of the colon, prostate, pancreas, breast and endometrium (uterine lining). Endometrial cancer is the fourth most common cancer in women in the United States and is expected to affect 40,000 women in 2005. Approximately 40% of endometrial cancer may be attributed to obesity and this is thought to be primarily due to the increased estrogen production in adipocytes (fat cells) through the conversion of androgens to estrogens. Yet not all obese women will develop endometrial cancer suggesting that other factors aside from the increased estrogen must also play a role in the process of malignant transformation. Protective factors in obese women include physical activity but the exact mechanisms that underlie such protection remain poorly understood. Little prospective data exist on adipocyte derived factors or physical activity levels in overweight and obese women. Therefore, the purpose of this study is prospectively collect baseline physical activity measures, baseline body mass index, baseline hormonal levels, blood/fat samples, and endometrial samples from overweight and obese postmenopausal women who are undergoing hysterectomy. After collection, we will explore and identify differences in either fat or blood biomarkers or in physical activity levels in women with and without endometrial cancer. The goal of this research is to better define risk factors in postmenopausal overweight and obese women that predispose to endometrial cancer and to identify any protective factors that correlate with physical activity. The ultimate goal of the research is to be able to predict, and perhaps to eventually prevent, the development of endometrial cancer in obese women.