MECHANISMS OF INDUCED ASTHMA IN HIGHLY TRAINED SWIMMERS

训练有素的游泳者诱发哮喘的机制

• 批准号: 7725038
• 负责人: Lori J. Wilson
• 金额: $ 5.68万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7725038
• 关键词: Acute; Affect; Asthma; Attenuated; Computer Retrieval of Information on Scientific Projects Database; Conflict (Psychology); Event; Exercise; Exercise-Induced Asthma; Funding; Goals; Grant; Hormones; Immune response; Immune system; Institution; Literature; Play; Published Comment; Research; Research Personnel; Resources; Role; Seasons; Source; Stress; Swimming; Training; United States National Institutes of Health; base; fitness; fluorouracil/melphalan/tamoxifen; immune function; pulmonary function; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this research is to increase our understanding of the role that fitness and intense exercise training plays in exercise induced asthma. The current literature shows conflicting viewpoints on this topic and no one has looked at the linkage between immune function and EIB in highly trained athletes. The research questions to be answered directly by this study are: Hypothesis #1: In highly trained swimmers, how do the pulmonary function and immune system responses to an acute bout of exercise differ for asthmatics and healthy controls? - What are the baseline circulating levels differences? - Is there a more or less robust immune response to the exercise challenge for asthmatics? Hypothesis #2: Does intense swim exercise training alter PFT and immune response across a training season? - compare the acute response to an exercise challenge before and after a training season to do determine if training attenuates immune response. Hypothesis #3: Is there a unique additive affect of a stressful competitive event that alters PFT and immune response? -Compare field based stress hormone levels and immune response to lab based levels

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的总体目标是提高我们对健身和强烈运动训练在运动引起的哮喘中发挥作用的作用的理解。 当前的文献对该主题表现出了矛盾的观点，没有人研究过训练有素的运动员中免疫功能与EIB之间的联系。 这项研究要直接回答的研究问题是： 假设1：在训练有素的游泳者中，肺功能和免疫系统对急性运动的反应在哮喘患者和健康对照方面有所不同？ - 基线循环级别的差异是什么？ - 对哮喘患者的运动挑战或多或少有强烈的免疫反应吗？ 假设2：激烈的游泳运动训练是否会在训练季节改变PFT和免疫反应？ - 比较训练季节之前和之后对运动挑战的急性反应，以确定训练是否减轻了免疫反应。 假设3：是否有改变PFT和免疫反应的压力竞争事件的独特加性影响？ - 基于磁场的应力激素水平和对基于实验室水平的免疫反应