PILOT, RANDOMIZED, DOUBLE-BLIND, CROSSOVER STUDY OF FISH OIL [EPA AND DHA] FO

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目标： 这项研究的主要目标是确定鱼油是否能减少癫痫患者的癫痫发作和心律失常的风险。这一基本假设将在一项试点临床试验中得到解决，该试验探索了以下两个具体目标： 具体目标1：获得关于鱼油与安慰剂在减少成人难治性癫痫发作频率方面的安全性和有效性的初步数据。 假设1a。对于癫痫患者来说，鱼油是安全且耐受性良好的。 假设1b。与安慰剂相比，在使用鱼油进行积极治疗期间，癫痫发作的频率和严重程度都有所降低。 假设1c。癫痫患者服用补充剂后，N-3脂肪酸EPA和DHA水平显著升高，并与疗效相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS: The primary goal of this study is to determine if Fish Oil reduces seizures and the risk of cardiac arrhythmias in people with epilepsy. This fundamental hypothesis will be addressed in a pilot clinical trial, which explores the following two specific aims: Specific Aim 1: To obtain preliminary data regarding the safety and effectiveness of Fish Oil compared with placebo in reducing seizure frequency in adults with intractable epilepsy. Hypothesis 1a. Fish Oil is safe and well tolerated in subjects with epilepsy. Hypothesis 1b. Seizure frequency and severity is reduced during active treatment with Fish Oil compared with placebo. Hypothesis 1c. Levels of the N-3 fatty acids, EPA and DHA, rise significantly in epileptic patients after supplementation, and are correlated with response.