ISOLATED MUSCLE TRAINING BEFORE AND AFTER LUNG TRANSPLANTATION IN HUMANS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Test whether the inability of patients to regain normal exercise tolerance after recovery from lung transplantation is due to skeletal muscle myopathic changes that contribute significantly to exercise limitation. Skeletal muscle myopathic changes may originate from either a muscle specific disease connected to the original disease state (mainly COPD), action of the immunosuppressive therapies used after transplant, or a disuse atrophy resulting from the long term nature of the original disease.