NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) DATABASE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 非酒精性脂肪性肝病（NAFLD）是一系列与脂肪积聚相关的肝脏疾病，范围从良性、非进行性肝脏脂肪积聚到严重肝损伤、肝硬化和肝功能衰竭。 目前，对于NASH还没有确定的有效治疗方法，并且其自然史和预后还不清楚。 印第安纳州大学是NIDDK资助的非酒精性脂肪性肝炎临床研究网络（NASH CRN）的临床中心之一。 “非酒精性脂肪性肝病（NAFLD）数据库”是NASH CRN提出的倡议之一。该数据库的目的是开发NAFLD患者的多中心登记，并进行相关的临床研究。预计将在全国范围内招募多达1500名NAFLD患者，招募儿童和成人。在该研究中心，我们计划入组200例NAFLD患者（150例成人和50例儿童）。NAFLD数据库将收集信息，使研究人员能够解决与NAFLD的病因、发病机制和自然史相关的某些假设。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver conditions associated with fat accumulation that ranges from benign, non progressive liver fat accumulation to severe liver injury, cirrhosis, and liver failure. Currently, there is no established effective therapy for NASH, and its natural history and prognosis are not well understood. Indiana University is one of the Clinical Centers for the NIDDK funded Non-alcoholic steatohepatitis Clinical Research Network (NASH CRN). The "Non-alcoholic Fatty Liver Disease (NAFLD) Database" is one of the initiatives proposed by the NASH CRN. The objective of this database is to develop a multicenter registry of patients with NAFLD and to conduct pertinent clinical research. It is anticipated that up to 1500 patients with NAFLD will be enrolled nationwide and both children and adults will be recruited. At this site, we plan to enroll 200 patients with NAFLD (150 adults and 50 children). The NAFLD Database will collect information that will enable the investigators to address certain hypotheses pertinent to the etiology, pathogenesis, and natural history of NAFLD.