YOGA STRESS REDUCTION SUB-STUDY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目标 主要研究目标 1.比较积极治疗组和对照组在影响和睡眠质量(问卷调查)方面的变化(基线为6个月)。 2.比较积极治疗组和对照组交感神经系统活动的变化(基线至6个月)(通过测量静息心率、静息血压和静息尿中肾上腺素和去甲肾上腺素水平)和皮质肾上腺活动指数(通过测量唾液和尿液中的皮质醇和腰臀比)。 3.比较积极治疗组和对照组在慢性炎症(C-反应蛋白水平)和免疫功能(唾液免疫球蛋白IgA水平)方面的变化(基线至6个月)。 次要研究目标 4.比较两组患者睡前唾液褪黑素水平的变化(基线至6个月)。 5.检查影响的变化(基线至6个月)与循环皮质醇变化以及唾液褪黑素变化与睡眠质量变化之间的相关性。 6.评估瑜伽干预在试验期间实现的压力标记的变化是否在接下来的6个月(维持阶段)持续。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS Primary Study Aims 1. To compare change (baseline to 6 months) in affect and sleep quality (using questionnaires) between the active treatment and the control groups. 2. To compare change (baseline to 6 months) in sympathetic nervous system activity (using measurements of resting heart rate, resting blood pressure, and resting levels of adrenalin and noradrenalin in the urine) and an index of cortical adrenal activity (using measurements of cortisol in the saliva and urine and waist-to-hip circumference ratio) between the active treatment and the control groups. 3. To compare change (baseline to 6 months) in chronic inflammation (measured by blood levels of C-reactive protein) and immune function (measured by salivary levels of immunoglobulin IgA) between the active treatment and the control groups. Secondary Study Aims 4. To compare change (baseline to 6 months) in salivary melatonin level at bedtime between the active treatment and the control group. 5. To examine the correlations between change (baseline to 6 months) in affect and change in circulating cortisol and between change in salivary melatonin and change in sleep quality. 6. To assess whether the changes in stress markers achieved by the yoga intervention during the trial are sustained over the following 6 months (during the maintenance phase).