ASSESSING NEURAL MECHANISMS OF INJURY IN INBORN ERRORS OF UREA METABOLISM

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究项目将研究运动和认知功能的大脑基础，以及受尿素代谢先天错误影响或携带者在学习方面遇到的任何困难。这项研究的目标是对典型发育成熟的人进行行为测试和核磁共振检查，并将其与一组患有先天性尿素代谢错误的人进行比较，尿素代谢错误可能会影响认知和运动功能。这项研究是基于之前的一项工作，证明了一些鸟氨酸转氨酶缺乏基因携带者的学习问题。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research project will study the brain basis of motor and cognitive functions and any difficulties in learning experienced by individuals who are affected by or carriers of inborn errors of urea metabolism. The goal of the study is to use behavioral testing and MRI procedures in typically developed people and compare this with a group of people with inborn erors of urea metabolism which may affect cognitive and motor function. This study is based upon a previous work demonstrating learning problems in some individuals who are carriers of the Ornithine transcarbamylase deficiency gene.