Clinical Translation Core

项目摘要 临床翻译核心（CTC）的总体目标是高效地 基本和应用智力和发育残疾研究（IDDR）的结果， 临床研究和最终的临床实践。反恐委员会的目的是作为“一站式”机构， 为碘缺乏病调查人员提供“购物”，直接或合作提供协助和服务 与其他机构资源（特别是临床和转化科学奖） （CTSA）计划）在临床和转化研究（CTR）的每个阶段， CNH、GW、GU和HU。这包括深入的表型分析、招募、表现、分析， 执行、商业化和传播。将协调拟议的气候技术中心， 由一个具有成本效益并提供具体基础设施支持的行政结构 供DC-IDDR调查人员及其团队使用。CTC的直接职能包括：1）数据 挖掘大型真实世界证据数据源（信息学）; 2）患者招募和研究 在多个地点的业绩; 3）生物统计学/信息学方面的咨询支持， 规划，设计和分析IDDR研究; 4）与其他组织的联系和合作 IDDRC核心，用于深度表型/基因分型和生物库，以及5）培训和 通过基于网络的调查工具包进行传播。具体目标是：（1）建立一个 表型组学框架，具有整合临床和“组学”数据的数字平台， 2）采用多维策略，以提高参与者的参与度 招募和研究实施/绩效; 3）提供IDDR相关研究设计， 生物统计和信息学支助;以及4）开发一个减灾十年调查工具包。

Project Summary The overall goal of the Clinical Translational Core (CTC) is to efficiently and effectively move basic and applied intellectual and developmental disability research (IDDR) findings into human clinical studies and ultimately clinical practice. The CTC is designed to serve as a “one-stop- shop” for IDD investigators, providing assistance and services either directly or in collaboration with other institutional resources (especially the Clinical and Translational Science Award (CTSA) program) at each stage of the clinical and translational research (CTR) spectrum at CNH, GW, GU and HU. This includes deep phenotyping, recruitment, performance, analysis, implementation, commercialization and dissemination. The proposed CTC will be coordinated by an administrative structure that is cost effective and provides specific infrastructure supports for DC-IDDR investigators and their teams. The direct functions of the CTC will include: 1) data mining of large real-world evidence data sources (informatics); 2) patient recruitment and study performance across multiple venues; 3) consultative support in biostatistics/informatics for planning, designing, and analyzing IDDR studies; 4) connection and collaboration with other IDDRC cores for deep phenotyping/genotyping and bio banking, and 5) training and dissemination through a web based investigator toolkit. The specific aims are: 1) To build a phenomics framework with a digital platform that integrates clinical and 'omics' data and a companion biorepository; 2) To employ a multi-dimensional strategy to enhance participant recruitment and study implementation/performance; 3) To provide IDDR-relevant study design, biostatistical and informatics support; and 4)To develop an IDDR investigator toolkit.