Investigating Health Effects From Exposure to Organic Carbon and Nickel Aerosol

描述（由申请人提供） 博士Richard Peltier的长期职业目标是成为一名能够领导先进的气溶胶暴露评估研究的独立调查员，为了解暴露及其特定的健康影响做出有目的的贡献。 在指导研究阶段（K99），Peltier博士将获得进行空间流行病学分析的专业知识，与国家健康信息数据集合作，改进暴露评估的新方法，并更好地了解与细颗粒镍暴露相关的健康影响。 博士陈龙志将担任主要导师，并监督候选人向独立研究员过渡的各个方面。 此外，一个由3名共同导师组成的团队将为候选人提供互补的研究方法，这将大大提高和多样化候选人的研究技能。 导师团队共同承诺指导候选人扩展其研究兴趣和方法，并确保成功过渡到独立研究人员。 在该奖项的独立阶段（R00），候选人将对心血管疾病的小鼠模型进行一系列体内暴露研究。 各种燃烧排放的气溶胶，其中包括与细颗粒镍增强，并通过不同程度的光化学处理，将用于解决与接触细颗粒气溶胶相关的健康后果。这项工作将导致一个更好的机制的理解，特别是侧重于镍和有机碳气溶胶，与细颗粒物暴露相关的氧化应激，并将导致更好地耦合体内暴露和更广泛的流行病学监测举措。

DESCRIPTION (provided by applicant) Dr. Richard Peltier's long term career goal is to become an independent investigator capable of leading advanced aerosol exposure assessment research that makes a purposeful contribution to understanding exposures and their specific health effects. During the mentored research phase (K99), Dr. Peltier will gain expertise in conducting spatial epidemiological analyses, working with national health information datasets, refining novel approaches to exposure assessment, and developing a better understanding of the health implications associated with exposure to fine particle nickel. Dr. Lung Chi Chen will serve as the primary mentor and oversee all aspects of the candidate's transition to an independent researcher. In addition, a team of 3 co-mentors will provide the candidate with complementary research approaches which will greatly enhance and diversify the candidate's research skill set. Together, the team of mentors has pledged to guide the candidate to extend his research interests and approaches, and to ensure a successful transition to an independent researcher. During the independent phase (R00) of this award, the candidate will conduct a series of in-vivo exposure studies on a murine model of cardiovascular disease. A variety of combustion emissions aerosol, which include enhancements with fine particle nickel, and processed by varying degrees of photochemistry, will be used to address health outcomes associated with exposure to fine particle aerosol. This work will lead to a better mechanistic understanding, with a particular focus on nickel and organic carbon aerosol, of the oxidative stress associated with fine particle exposures, and will lead to a better coupling of in-vivo exposure and broader scale epidemiological surveillance initiatives.