APOE RECEPTOR SPLICING, GENETICS, AND AD

APOE 受体剪接、遗传学和 AD

• 批准号: 7580202
• 负责人: Steven Estus
• 金额: $ 30.43万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7580202
• 关键词: Alleles; Alzheimer' s Disease; Apolipoprotein E; Arts; Autopsy; Biological Assay; Biology; Blood - brain barrier anatomy; Brain; Cell surface; Cells; Cleaved cell; Collaborations; Complex; Computer Simulation; Computer software; DNA; Data; Disease; Disease Association; Early Diagnosis; Employee Strikes; Enhancers; Etiology; Evaluation; Exons; Extracellular Domain; Extracellular Space; Family member; Foundations; Gene Expression; Generations; Genetic; Genetic Polymorphism; Genetic Variation; Genotype; Haplotypes; Human; In Vitro; Individual; Kentucky; LDL-Receptor Related Protein 1; Length; Link; Mediating; Messenger RNA; Nerve Degeneration; Phase; Population; Predisposition; Protein Isoforms; Proteins; Proteolysis; Proteomics; RNA Splicing; Reagent; Relative (related person); Religion and Spirituality; Research; Rest; Role; Sampling; Single Nucleotide Polymorphism; Site; Staging; Testing; Therapeutic Uses; Transmembrane Domain; Universities; Variant; Work; apolipoprotein E receptor 2; apolipoprotein E-4; base; brain tissue; genetic association; genetic risk factor; genetic variant; in vivo; innovation; insight; male; member; novel; population based; programs; protein expression; receptor; receptor expression; receptor function; stable cell line; success; sugar

these studies are significant and innovative because they have strong relevance to our understanding of the possible mechanistic etiology of AD, potentially facilitating therapy, and to AD genetics, facilitating early diagnosis and treatment.

这些研究意义重大且具有创新性，因为它们 与我们对 AD 可能病因学的理解有很强的相关性， 促进治疗，以及AD遗传学，促进早期诊断和治疗。