High Performance CMOS Based X-Ray Detector for C-AM CT Imaging

描述（由申请人提供）：图像引导微创治疗允许快速有效的治疗，失血量低。但这在很大程度上取决于成像系统。C形臂CT成像提供常规二维（2D）和3D容积成像，用于术中导航和评估。然而，基于平板检测器（FPD）的这些系统强加了空间分辨率、视场（FOV）、帧速率和图像噪声之间的权衡。一种新的检测器与碘化汞涂层互补金属氧化物半导体（CMOS）芯片预计将解决这些问题。它将允许以120帧/秒的速度进行120微米像素的大视场成像，并且噪声仅为500 e rms。该提案旨在优化其Carm CT成像的设计和性能。这将在中风治疗中特别有用。 CMOS探测器的分阶段开发将涉及成像链的理论建模，以预测其性能。我们的合作者准备的面板的成像特性将在台式CT系统上进行测试，并与这些预测进行比较。将识别任何图像退化过程，并修改探测器设计。将检查和优化由平铺芯片（10.5cmx11cm和22 cmx 28 cm）构建的成像面积增加的面板。将考虑X线透视、血管造影和灌注CT成像，并与FPD的性能进行比较。将评价减少剂量的机会。最终，将在双平面C形臂机架上安装两个22 cm x 28 cm探测器。 将在犬卒中模型中进行闭塞前后的血流和灌注的体内成像，并与临床CT扫描的结果进行比较。将制定一项利用探测器最大潜力的成像协议。 该提案的技术创新在于能够使用这种独特的大面积高速探测器来提取最大的2D信息，特别是3D信息，以帮助微创手术。 研究的相关性：该提案旨在改善图像引导干预， 重要性日益增加，因为与传统技术相比，它们可以更快地回收并降低成本 手术这将通过开发一种用于X射线检测的摄像机来实现，该摄像机将允许类似CAT扫描 成像沿着实时观察用于中风治疗的脑中仪器的操作。

DESCRIPTION (provided by applicant): Image guided minimally invasive therapies allow rapid and effective treatments with low blood loss. But it depends heavily on the imaging system. C-arm CT imaging provides conventional two dimensional (2D) and 3D volumetric imaging for intra-procedural navigation and assessment. These systems, based on flat panel detectors (FPD) however, impose trade-offs between spatial resolution, field of view (FOV), frame rate, and image noise. A novel detector with a mercuric iodide coated Complimentary Metal Oxide Semiconductor (CMOS) chip is expected to address these problems. It will allow large FOV imaging with 120 micron pixels at 120 frames/s and only 500e rms noise. The proposal aims to optimize its design and performance for Carm CT imaging. This will be particularly useful in stroke treatment. The staged development of the CMOS detector will involve theoretical modeling of the imaging chain to predict its performance. The imaging characteristics of panels prepared by our collaborator will be tested on a table-top CT system and compared with these predictions. Any image degradation processes will be identified and the detector design will be modified. Panels with increasing imaging area built from tiled chips (10.5cmx11cm and 22cmx28cm) will be examined and optimized. Fluoroscopic, angographic and perfusion CT imaging will be considered and compared with the performance of an FPD. Opportunities for reduction in dose will be evaluated. Eventually two 22cmx28cm detectors will be implemented on a biplane C-arm gantry. In vivo imaging of flow and perfusion pre and post occlusion in a canine stroke model will be conducted and compared with results from a clinical CT scan. An imaging protocol that utilizes the maximum potential of the detector will be developed. The technical innovations of the proposal lie in the ability to use this unique large area high speed detector for extracting maximum 2D, and particularly, 3D information for aiding minimally invasive procedures. RELEVANCE OF RESEARCH: This proposal aims to improve image guided interventions which are growing in importance since they allow quicker reovery and reduce costs compared to conventional surgeries. This will be achieved by developing a camera for x-ray detection that will allow CATscan-like imaging along with viewing in realtime the manipulation of insturments in the brain for stroke treatment.