LUNG FUNCTION MEASURES IN PRESCHOOL CHILDREN WITH CYSTIC FIBROSIS

这个子项目是众多研究子项目之一

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. With the awareness that cystic fibrosis (CF) lung disease begins early in life and often prior to the onset of symptoms, there is increasing recognition of the need for multicenter clinical trials in young CF patients. Unfortunately, clinical investigations in this critical young population have been hindered by the lack of appropriate outcome measures, particularly measures of lung function. The proposed study is a prospective, longitudinal, descriptive, multi-center investigation of three promising lung function measures (spirometry, inductance plethymography (IP) and forced oscillometry (FO)) in preschool aged children with CF and in healthy control subjects, with the objective of assessing their utility as outcome measures for clinical trials in preschool CF patients. The study will utilize standardized equipment and testing procedures, rigorous training of study personnel, and ongoing quality control review of all primary data by an expert panel. In order to gain and document the required expertise in preschool lung function testing, each site will enroll preschool subjects without CF in a separate ¿certification protocol¿ prior to enrolling any subjects in the preschool lung function study.