EFFECT OF SIMVASTATIN ON CYSTIC FIBROSIS AIRWAY INFLAMMATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 囊性纤维化(CF)患者有持续的呼吸道感染，身体试图通过向肺招募免疫细胞(中性粒细胞)来对抗这种感染。免疫系统和中性粒细胞无法完全杀死细菌，对感染的反应会导致呼吸道发炎(肿胀)和肺损伤。一氧化氮(NO)在肺部具有抗细菌和抗炎的特性。在CF患者中，NO的产生减少，并可能参与持续感染和炎症。增加CF患者呼吸道中NO的产生可能有助于减轻这种炎症和感染。这项研究将验证给予辛伐他汀(Zocor)会增加囊性纤维化受试者呼出的一氧化氮(ENO)和降低呼吸道炎症标志物的假设。这是一项多中心的前瞻性研究，旨在研究口服辛伐他汀28天对10岁及以上囊性纤维化患者的鼻腔上皮样本和诱导痰样本中呼出的一氧化氮和呼吸道炎症指标的影响。这项研究还将探索鼻腔上皮细胞作为降低呼吸道炎症的替代标记物的使用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Individuals with cystic fibrosis (CF) have persistent infection in the airways, which the body attempts to fight by recruiting immune cells (neutrophils) to the lung. The immune system and neutrophils are unable to completely kill the bacteria, and the response to the infection leads to inflammation (swelling) of the airways and lung damage. Nitric oxide (NO) has anti-bacterial and anti-inflammatory properties in the lung. NO production is decreased in CF patients, and may contribute to the persistent infection and inflammation. Increasing the production of NO in the airways of CF patients may help decrease this inflammation and infection. This study will test the hypothesis that the administration simvastatin (Zocor¿) will increase exhaled nitric oxide (eNO) and decrease markers of airway inflammation in subjects with cystic fibrosis. This is a multi-center, prospective study examining the effects of 28 days of oral simvastatin (Zocor¿) treatment on exhaled nitric oxide and measures of airway inflammation in nasal epithelial samples and induced sputum samples in patients with cystic fibrosis (CF) ages 10 and older. This study will also explore the use of nasal epithelial cells as surrogate markers for lower airway inflammation.