MICHIGAN ALZHEIMER'S DISEASE RESEARCH CENTER UM-MAP

密歇根阿尔茨海默病研究中心 UM-MAP

• 批准号: 7603822
• 负责人: BRUNO GIORDANI
• 金额: $ 0.93万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603822
• 关键词: Advocate; Affect; African American; Age; Aging; Alzheimer' s Disease; Autopsy; Caring; Clinical; Clinical Research; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Consent; Data; Data Set; Databases; Dementia; Diagnosis; Diagnostic; Disease; Education; Educational Materials; Enrollment; Ensure; Family Practice; Funding; Grant; Guidelines; Healthcare; Hispanics; Individual; Institution; Learning; Medical; Medical Records; Memory; Michigan; Minority; Monitor; Names; Neurologic; Participant; Patients; Persons; Population Research; Research; Research Ethics Committees; Research Personnel; Research Project Grants; Resources; Screening procedure; Source; Symptoms; Thinking; Time; United States National Institutes of Health; Universities; interest; neuropsychological; normal aging; treatment center; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The University of Michigan Memory and Aging Project (UM-MAP) within the Michigan Alzheimer's Disease Research Center (MADRC) is being performed to learn more about the types of symptoms that develop in patients with Alzheimer's disease and related disorders during the course of their illness. Participants in the study do not have to change their regular medical care. By observing how symptoms change over time, we hope to learn more about when and why particular symptoms develop and how this affects treatment. The Clinical Core, the Administrative Core, and the Education Core are the primary MADRC cores involved in this project. The Clinical Core serves as the primary contact point for the study volunteer and in collaboration with the Education and Administrative cores, assists with educational materials and activities to promote participation in clinical studies, stimulates the interest of trainees and new investigators, and disseminates research advances widely. The Minority Satellite Diagnostic and Treatment Center at the Ypsilanti Family Practice Center in the Clinical Core serves a large African-American and Hispanic community and ensures a diverse research population from which to draw potential volunteers. Individuals invited to enter UM-MAP include volunteers with normal aging and patients with mild Alzheimer's disease or other difficulties that can affect memory or thinking ability. Once a participant enrolls, he or she must 1) identify a study partner who serves as an informant, 2) name a health care advocate (preferably the same person as the health care advocate), and 3) agree to an annual neurological and neuropsychological screening examination at the University of Michigan General Clinical Research Center. The volunteer is also encouraged to give provisional consent for autopsy as Alzheimer's disease and related illnesses are only confirmed upon autopsy. As part of the study, medical records from the participant's regular Alzheimer's care will also be reviewed to monitor clinical changes that may affect the research diagnosis. The data collected during the annual screening exams, called the Universal Data Set (UDS) will be used in three ways: 1) investigators or the volunteer's clinician may access relevant data to monitor a participant's progression, 2) separate research projects that are approved by the IRB and the Executive Committee may use data for research on dementia, and 3) the data will also be stored in a national database at the National Alzheimer's Coordinating Center(NACC) that pools information from all NIH-funded Alzheimer's Disease Centers under guidelines meeting all HIPPA requirements.'

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 密歇根大学记忆和衰老项目（UM-MAP）在密歇根州阿尔茨海默病研究中心（MADRC）正在进行，以了解更多关于阿尔茨海默病和相关疾病患者在疾病过程中出现的症状类型。研究参与者不必改变他们的常规医疗护理。通过观察症状如何随着时间的推移而变化，我们希望更多地了解特定症状何时以及为什么会出现以及这如何影响治疗。临床核心、行政核心和教育核心是本项目涉及的主要MADRC核心。临床核心作为研究志愿者的主要联系点，与教育和管理核心合作，协助提供教育材料和活动，以促进参与临床研究，激发学员和新研究者的兴趣，并广泛传播研究进展。位于临床核心的Ypsilanti家庭实践中心的少数民族卫星诊断和治疗中心为大型非洲裔美国人和西班牙裔社区提供服务，并确保吸引潜在志愿者的多样化研究人群。 被邀请进入UM-MAP的个人包括正常衰老的志愿者和患有轻度阿尔茨海默病或其他可能影响记忆或思维能力的困难的患者。一旦参与者注册，他或她必须1）确定一个研究伙伴谁作为线人，2）名称的医疗保健倡导者（最好是同一个人作为医疗保健倡导者），和3）同意每年在密歇根大学一般临床研究中心神经和神经心理筛查检查。还鼓励志愿者临时同意尸检，因为阿尔茨海默病和相关疾病只有在尸检时才能得到证实。作为研究的一部分，还将审查参与者定期阿尔茨海默氏症护理的医疗记录，以监测可能影响研究诊断的临床变化。在年度筛选检查期间收集的数据，称为通用数据集（UDS），将以三种方式使用：1）研究者或志愿者的临床医生可以访问相关数据以监测参与者的进展，2）由IRB和执行委员会批准的单独研究项目可以使用痴呆症研究数据，以及3）数据还将存储在国家阿尔茨海默氏症协调中心（NACC）的国家数据库中，该数据库根据符合所有HIPPA要求的指南汇集了所有NIH资助的阿尔茨海默氏症中心的信息。'