AUTOIMMUNE MECHANISMS IN DIABETIC NEUROPATHY

糖尿病神经病的自身免疫机制

• 批准号: 7603703
• 负责人: JOHN W WILEY
• 金额: $ 0.16万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603703
• 关键词: Affect; Antibodies; Autoimmune Process; Blood; Blood donor; Calcium; Cell Death; Complications of Diabetes Mellitus; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Diabetic Neuropathies; Diagnosis; Disease; Eye; Funding; Grant; Hand; Hormones; Immune system; Institution; Insulin; Kidney; Laboratories; Lead; Nerve; Nervous system structure; Neurons; Organ; Patients; Proteins; Research; Research Personnel; Resources; Skin; Source; Tissues; United States National Institutes of Health; diabetic; foot; sugar

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Diabetes mellitus is a very common disease caused by a lack of the hormone insulin (which regulates sugar) or an inability of tissues to use insulin. Five to 15 years after being diagnosed with diabetes most patients develop some type of complications involving the eyes, kidneys, nervous system and/or skin. These complications can be debilitating and costly. Nerve damage is one of the most common complications of diabetes and can affect the nerves of the hands and feet, as well as the nerves that regulate internal organs and vital body functions. In our laboratory, recent studies indicate that, in diabetics, there is increased calcium inside nerve cells (neurons) and increased nerve cell death. We have reason to believe that the body's own immune system may contribute to these problems. Therefore we wish to analyze the blood from insulin dependent and non-insulin dependent diabetic patients with and without nerve damage and compare it to the blood from normal healthy blood donors. We will be looking for proteins (antibodies) found in the blood, produced by the immune system. Through this study we hope to gain a better understanding of factors in the blood that may lead to nerve damage in diabetes mellitus and that may eventually aid in new treatments.'

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 糖尿病是一种非常常见的疾病，是由于缺乏胰岛素（调节糖分）或组织无法使用胰岛素而引起的。大多数患者在被诊断患有糖尿病后 5 至 15 年会出现某种类型的并发症，涉及眼睛、肾脏、神经系统和/或皮肤。这些并发症可能会让人衰弱且代价高昂。神经损伤是糖尿病最常见的并发症之一，会影响手脚神经以及调节内脏器官和重要身体功能的神经。在我们实验室，最近的研究表明，糖尿病患者的神经细胞（神经元）内钙含量增加，神经细胞死亡增加。我们有理由相信人体自身的免疫系统可能导致这些问题。因此，我们希望分析有或没有神经损伤的胰岛素依赖型和非胰岛素依赖型糖尿病患者的血液，并将其与正常健康献血者的血液进行比较。 我们将寻找血液中由免疫系统产生的蛋白质（抗体）。通过这项研究，我们希望更好地了解血液中可能导致糖尿病神经损伤的因素，并最终有助于新的治疗方法。