AUTOIMMUNE MECHANISMS IN DIABETIC NEUROPATHY

糖尿病神经病的自身免疫机制

• 批准号: 7603776
• 负责人: JOHN W WILEY
• 金额: $ 1.65万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603776
• 关键词: Affect; American; Antibodies; Autoantibodies; Autoimmune Process; Blood; Cells; Complication; Computer Retrieval of Information on Scientific Projects Database; Development; Diabetes Mellitus; Diabetic Neuropathies; Diagnosis; Enrollment; Evaluation; Eye; Feeling; Funding; Future; Grant; Immune system; Infection; Injury; Institution; Kidney; Lead; Leg; Natural History; Nervous System Physiology; Nervous system structure; Neurons; Newly Diagnosed; Non-Insulin-Dependent Diabetes Mellitus; Numbers; Numbness; Pain; Participant; Patients; Play; Proteins; Reporting; Research; Research Personnel; Resources; Role; Source; Testing; Time; Tissues; United States National Institutes of Health; design; diabetic; foot; healthy volunteer; injured; nerve injury

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Does the body's immune system play a role in the development of problems involving the nervous system in people with diabetes? Diabetes is known to be connected with problems involving the eyes, kidneys and nervous system. Little is known about why people develop problems with their nervous system in diabetes. Patients with diabetes report: -Pain -Tingling -Numbness and loss of feeling in their feet and legs. An increased number of antibodies in the blood that can attach to nerve cells and injure the nerve cells have been reported in patients with diabetes. Antibodies are proteins made by your body. The antibodies protect you from infections. Sometimes our body will make antibodies that attach to our own tissues. This type of antibody injures the tissues. These antibodies are called autoantibodies. It is not known why or when these autoantibodies develop in diabetes. We don't know whether these antibodies contribute to the development of complications involving the nervous system. Our study is designed to help answer the following questions: 1. When do antibodies begin to appear in people with diabetes? 2. Does the presence of antibodies increase over time? 3. Do the antibodies attach to nerve cells? 4. If these antibodies attach to nerve cells, what are they specifically attaching to? 5. Do these antibodies injure nerve cells? 6. If the antibodies cause injury to nerve cells, how does this happen? We hope that answering these questions will lead to better treatments for the nervous system problems associated with diabetes in the future. Type 2 Diabetes is the most common form of diabetes and it affects millions of Americans every year. We will examine the hypothesis that a significant percentage of patients with Type 2 Diabetes will slowly develop autoantibodies during the course of their illness and that these autoantibodies contribute to the injury and loss of cells in the nervous system, a well-known complication in long-term diabetic patients. A total of 120 people 18 years or older will be enrolled into this study. Two groups of people with Type 2 Diabetes and one group of healthy volunteers will be studied. Group 1 will include people with Type 2 Diabetes newly diagnosed and up to 2 years prior to their start in this study. Group 2 will include people with Type 2 Diabetes diagnosed 7 to 9 years prior to their start in this study, and Group 3 will include healthy volunteers. All groups will undergo a thorough examination of their nervous system function and have blood drawn to screen for the presence of autoantibodies. All participants will undergo re-evaluation between four to five years after the initial testing. These studies will help to determine the significance of autoimmune mechanisms in the natural history of nerve injury that occurs in Type 2 Diabetes Mellitus.'

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 身体的免疫系统是否在糖尿病患者神经系统问题的发展中发挥作用？ 众所周知，糖尿病与涉及眼睛、肾脏和神经系统的问题有关。 人们对为什么糖尿病患者的神经系统会出现问题知之甚少。 糖尿病患者报告： - 疼痛 - -刺痛 - 麻木和失去感觉在他们的脚和腿。 据报道，糖尿病患者血液中抗体的数量增加，这些抗体可以附着在神经细胞上并损伤神经细胞。抗体是由身体产生的蛋白质。 抗体保护你免受感染。 有时我们的身体会产生抗体，附着在我们自己的组织上。 这种抗体会损伤组织。 这些抗体被称为自身抗体。 目前尚不清楚这些自身抗体在糖尿病中产生的原因和时间。 我们不知道这些抗体是否会导致神经系统并发症的发生。 我们的研究旨在帮助回答以下问题： 1.糖尿病患者体内抗体何时开始出现？ 2.抗体的存在会随着时间的推移而增加吗？ 3.抗体会附着在神经细胞上吗？ 4.如果这些抗体附着在神经细胞上，它们具体附着在什么地方？ 5.这些抗体会损伤神经细胞吗？ 6.如果抗体导致神经细胞损伤，这是如何发生的？ 我们希望，这些问题的答案将导致未来更好地治疗与糖尿病相关的神经系统问题。 2型糖尿病是最常见的糖尿病形式，每年影响数百万美国人。 我们将研究一个假设，即有相当比例的2型糖尿病患者在其疾病过程中会慢慢产生自身抗体，这些自身抗体会导致神经系统细胞的损伤和丢失，这是长期糖尿病患者的一个众所周知的并发症。 共有120名18岁或以上的受试者将入组本研究。 将研究两组2型糖尿病患者和一组健康志愿者。 第1组将包括新诊断的2型糖尿病患者，并且在他们开始本研究之前长达2年。 第2组将包括在本研究开始前7至9年诊断为2型糖尿病的患者，第3组将包括健康志愿者。 所有组都将接受神经系统功能的彻底检查，并抽血筛查自身抗体的存在。所有参与者将在初次测试后的四到五年内接受重新评估。这些研究将有助于确定自身免疫机制在2型糖尿病神经损伤自然史中的重要性。'