USE OF LORAZEPAM FOR THE TREATMENT OF PEDIATRIC STATUS EPILEPTICUS

劳拉西泮用于治疗小儿癫痫持续状态的用途

• 批准号: 7603799
• 负责人: RACHEL M STANLEY
• 金额: $ 0.09万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603799
• 关键词: Accident and Emergency department; Adverse effects; Age; Applied Research; Benzodiazepines; Blood; Blood specimen; Brain Injuries; Breathing; Child; Childhood; Computer Retrieval of Information on Scientific Projects Database; Consent Forms; Dose; Emergency Care; Ethnic Origin; Funding; Gender; Goals; Grant; Hearing; Hour; Institution; Lorazepam; Medicine; Numbers; Patients; Persons; Pharmaceutical Preparations; Purpose; Race; Recording of previous events; Research; Research Personnel; Resources; Seizures; Source; Status Epilepticus; Telephone; Telephone Interviews; Thinking; Time; United States National Institutes of Health; Veins; day

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Status epilepticus (SE) is a term used when a person has a long seizure or many seizures at one time. Most doctors agree that treatment should be started right away to stop brain damage. Most patients come to an emergency room during or shortly after their seizure and treatment is usually started without a seizure doctor being in the emergency room. A study which looks at these types of seizures should happen where these patients are most often treated. Patients who come to the ER with these types of seizures are treated with drugs to stop the seizure. By giving the medicine we think that this will help the patient get better and will reduce possible brain damage later on. The drug we want to study is a type of drug called benzodiazepines. These kinds of drugs are thought to be the best drugs for the treatment of SE. These types of drug may have side effects, the worst being slowing or stopping of breathing. Slowing or stopping of breathing is the most common side effect of giving these drugs in the emergency room. Information on how safe and how effective these drugs are in children is rare. The drug we want to study is called lorazepam. The main goal of this study is to determine how a single dose of lorazepam behaves in the body. The medicine will be given through the veins to children with seizures or a history of seizures aged from 3 months to 18 years. Nobody will be excluded because of gender, race, or ethnicity. Eleven ERs from the Pediatric Emergency Care Applied Research Network (PECARN) will take part in this study. Patients will have a few blood samples taken at different times if they are suitable for this study, agree to take part and their guardian is willing to sign a consent form after hearing about the study. The blood will be drawn at different times during the next 48 hours after starting the study. Guardians of children in this study will be called by telephone for an interview over the phone 7-10 and 30-40 days after taking part in this study. Children in this study will be known only by numbers that are given to them for study purposes.'

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 癫痫持续状态（SE）是一个术语，当一个人有一个长时间的癫痫发作或多次癫痫发作在同一时间。大多数医生都认为应该立即开始治疗以阻止脑损伤。大多数患者在癫痫发作期间或癫痫发作后不久来到急诊室，通常在没有癫痫发作医生的情况下开始治疗。一项针对这些类型癫痫发作的研究应该发生在这些患者最常接受治疗的地方。患有这些类型癫痫发作的患者到急诊室接受药物治疗以阻止癫痫发作。我们认为通过给药，这将帮助病人好转，并减少以后可能的脑损伤。我们想研究的药物是一种叫做苯二氮卓类的药物。这类药物被认为是治疗SE的最佳药物。 这些类型的药物可能有副作用，最严重的是减缓或停止呼吸。 呼吸减慢或停止是在急诊室给予这些药物最常见的副作用。关于这些药物在儿童中的安全性和有效性的信息很少。我们要研究的药物叫劳拉西泮。本研究的主要目的是确定单剂量劳拉西泮在体内的行为。该药物将通过静脉给予癫痫发作或有癫痫发作史的3个月至18岁的儿童。没有人会因为性别、种族或民族而被排除在外。 来自儿科急诊应用研究网络（PECARN）的11名ER将参加本研究。 如果患者适合参加本研究，同意参加，并且其监护人在听说本研究后愿意签署知情同意书，则将在不同时间采集一些血液样本。将在研究开始后48小时内的不同时间采血。 本研究中儿童的监护人将在参加本研究后7-10天和30-40天通过电话进行访谈。 本研究中的儿童将仅通过为研究目的而提供的数字来了解。'