CHRONIC KIDNEY DISEASE IN CHILDREN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究是为了调查是什么因素导致慢性肾脏病(CKD)在儿童中恶化。慢性肾脏病是指肾脏在清除血液中的废物时遇到困难。慢性肾脏病患者的数量继续增长，到2010年，大约有65万美国人将患有慢性肾脏病。由于慢性肾脏病在成人人群中的增加最为显著，因此很少有研究针对患有慢性肾脏病的儿童进行。然而，由于生长发育和神经认知发展在儿科年龄组中的重要性，儿童可能更容易受到 进展性CKD多于成人。此外，由于肾脏疾病通常是由原发的泌尿系问题或肾小球疾病引起的，而不是成人的糖尿病或高血压(HTN)等继发性过程，因此儿童肾脏疾病进展的风险因素和后果可能更清晰，不受其他复杂因素的影响。 为了治疗儿童慢性肾脏病引起的问题，有必要了解是什么导致慢性肾脏病恶化。这项研究的主要目标是确定哪些因素导致慢性肾脏病在儿童中恶化，并了解慢性肾脏病如何影响儿童S的大脑发育和行为、心脏功能、生长和总体幸福感。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research is being done to investigate what factors cause Chronic Kidney Disease (CKD) to become worse in children. CKD is when the kidneys have trouble removing waste products from the blood. The number of people with CKD continues to grow, and about 650,000 Americans will have CKD by the year 2010. Because the increase of CKD has been most dramatic in the adult population, few studies have been performed in children with CKD. However, because of the importance of growth and neurocognitive development in the pediatric age group, children are likely to be much more vulnerable to the effects of progressive CKD than adults. Additionally, as kidney disease is usually due to a primary urologic problem or glomerular disease rather than a secondary process such as diabetes or hypertension (HTN), as in adults, the risk factors and consequences of kidney disease progression, independent of other complicating factors, are likely to be clearer in children. In order to treat the problems caused by CKD in children, it is necessary to understand what causes CKD to get worse. The primary goals of this study are to determine what factors cause CKD to get worse in children, and to see how CKD affects a child s brain development and behavior, heart function, growth and general well-being.'