PREVALENCE OF OBSTRUCTIVE SLEEP APNEA IN PATIENTS W/ CSCR

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Central serous chorioretinopathy (CSCR) is a typically self-limited, idiopathic retinal disease, which can result in permanent visual disturbance or impairment. Although the cause of CSCR has not been determined, it is known to occur in patients with Type A personality, and in patients with increased endogenous or exogenous glucocorticoid or catecholamine levels. Indeed, studies have shown that patients with CSCR have increased levels of "stress hormones" - circulating catecholamines (epinephrine and norepinephrine) and cortisol. An association with high catecholamine levels is also seen in patients with obstructive sleep apnea (OSA), and cortisol has also been postulated to play a role this disease, as well. A recent pilot study conducted at the Kellogg Eye Center found patients with CSCR to be at increased risk for OSA compared to controls. This study used the Berlin Questionnaire, a validated research tool, which approximates sleep-study-proven apnea. With a sensitivity of 86% and specificity of 77%, the questionnaire is a reasonably good screening tool for identification of patients who should be considered for definitive polysomnographic testing for OSA. Because it relies upon patient self-reporting instead of direct measurement of hypopnea, it does not provide a definitive diagnosis of OSA. To determine whether there is a true association between these disease states, we aim to recruit CSCR patients and a control group to undergo polysomnograms to definitively diagnose OSA in a case-control designed study. If there is an association between OSA and CSCR, this information may help physicians screen for disease in these patient populations.'