DOSE ESCALATED WHOLE LIVER IRRADIATION W/HEPATIC ARTERIAL DRUG CHEMOTHERAPY

剂量递增的全肝照射联合肝动脉药物化疗

• 批准号: 7603718
• 负责人: WILLIAM D ENSMINGER
• 金额: $ 0.81万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603718
• 关键词: Abdominal Pain; Catheters; Chemoembolization; Combination Chemotherapy; Computer Retrieval of Information on Scientific Projects Database; Death Rate; Diarrhea; Disease; Dose; Flushing; Funding; Goals; Grant; Hepatic; Hepatic artery; Hypervascular; Infusion procedures; Injury; Institution; Liver; Malignant Carcinoid Syndrome; Monitor; Neuroendocrine Tumors; Patients; Pharmaceutical Preparations; Radiation therapy; Rate; Research; Research Personnel; Resources; Source; Streptozocin; Symptoms; Techniques; United States National Institutes of Health; Vascular blood supply; Week; Wheezing; chemotherapy; day; irradiation; response; tumor; tumor vascular supply

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Neuroendocrine tumors with tumor involvement of the liver are associated with a high death rate. Abdominal pain and carcinoid syndrome (diarrhea, flushing, wheezing) is very common with this disease. These tumors are generally hypervascular, meaning that they have a very good blood supply that can be used to deliver chemotherapy directly to the tumor. A hepatic arterial catheter will be placed by radiological techniques to access the tumor blood supply for this treatment. In this study patients will receive a combination of chemotherapy drugs via the blood supply to the tumor in the liver. FUDR will be given as a continuous arterial infusion. Streptozotocin will be given on 3 separate days as well via the hepatic artery. During this 12 day chemotherapy infusion patients will also receive radiation therapy to the liver. The dose of radiation therapy will be escalated during the study. After an 8 week break, patients will be re-admitted for chemoembolization. During chemoembolization the blood supply to the tumor is blocked with chemotherapy and an embolization agent. The primary goal of this study is to determine what dose of whole liver radiation therapy can safely be given with IA FUDR and Streptozotocin. A secondary goal is to determine the response rate in treated patients. Patients will be closely monitored for signs or symptoms of liver injury from treatments.'

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 累及肝脏的神经内分泌肿瘤与高死亡率相关。腹痛和类癌综合征（腹泻、潮红、喘息）在这种疾病中很常见。这些肿瘤通常血管丰富，这意味着它们具有非常好的血液供应，可用于将化疗直接输送到肿瘤。将通过放射技术放置肝动脉导管以获取肿瘤的血液供应以进行这种治疗。在这项研究中，患者将通过肝脏肿瘤的血液供应接受化疗药物的组合。 FUDR 将通过持续动脉输注的方式给予。链脲佐菌素也将通过肝动脉分三天注射。在这 12 天的化疗输注期间，患者还将接受肝脏放射治疗。研究期间放射治疗的剂量将逐步增加。休息 8 周后，患者将再次入院接受化疗栓塞治疗。在化疗栓塞期间，通过化疗和栓塞剂阻断肿瘤的血液供应。本研究的主要目标是确定 IA FUDR 和链脲佐菌素可以安全地进行全肝放射治疗的剂量。第二个目标是确定治疗患者的反应率。将密切监测患者因治疗而导致肝损伤的体征或症状。