Hand, foot and mouth disease death case characterization and population enterovir

手足口病死亡病例特征和人群肠病毒

• 批准号: 7861017
• 负责人: ZHANG JING
• 金额: $ 7.5万
• 依托单位: CHINESE CTR-DISEASE CONTROL/PREVENTION
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7861017
• 关键词: Hand; foot; mouth; disease; death

DESCRIPTION (provided by applicant): Epidemiological research on HFMD death cases Based on the assumption that the early use of antipyretic drugs and host factors are the risk factors of death, this research will focus a comparative analysis for mild, critical and death cases of hand, foot and mouth disease on early use of antipyretic drug type, host factors, pathogen factors. We try to identify/ the illness progress of death cases and related impact factors. Through the investigation, we try to describe the epidemiological features, clinical features, diagnosis, treatment and exposure history, and enhance the understanding about the severe case to provide evidence for reducing the fatality rate. 2. Population-based Virus Carriage Rate Survey In order to understand whether it is related between seasonal prevalence or outbreaks of the hand, foot and mouth disease with virus carriage rate in population, we will carry out population-based, one-year round enterovirus (EV71 and CoxA16, other enterovirus) carriage rate survey in one HFMD higher-prevalence and one lower-prevalence district or county of one province. Target groups include healthy people, normal people who have closely contacted with the severe cases or ordinary HFMD cases. The aim is to analyze the proportion and dynamic changes of silently infected among these different groups and its role in the spread of HFMD so as to support the formation of HFMD prevention and control strategies.

描述（申请人提供）：手足口病死亡病例的流行病学研究基于早期使用退热药物和宿主因素是死亡危险因素的假设，本研究将重点对手足口病轻、危、死亡病例早期使用退热药物种类、宿主因素、病原因素进行对比分析。我们试图识别死亡病例的病情进展和相关影响因素。通过调查，描述其流行病学特征、临床特征、诊断、治疗及暴露史，加深对重症病例的认识，为降低病死率提供依据。2.人群病毒携带率调查为了解手足口病季节性流行或暴发流行与人群病毒携带率是否存在相关性，我们将在一个省的一个手足口病高流行区和一个低流行区或县开展以人群为基础的为期一年的肠道病毒（EV71和CoxA16等肠道病毒）携带率调查。目标人群包括健康人群、与重症病例密切接触的正常人群或普通手足口病病例。分析不同人群中隐性感染者的比例、动态变化及其在手足口病传播中的作用，为制定手足口病防控策略提供依据。