Molecular mechanisms of intracellular growth, survival and pathogenicity

感染人类的真菌是一个主要的健康问题，特别是对那些免疫系统受损的人(例如。艾滋病、器官移植和癌症患者)。这些真菌通过逃避免疫系统而引起疾病，同时获得生长所需的营养。一些真菌通过寄生在宿主细胞内来逃避免疫系统；一个充满敌意和营养贫乏的环境。这个项目将研究我们已经证明的在宿主细胞内生长所必需的途径。这一知识将为治疗开辟新的途径。

Fungi which infect humans are a major health problem, especially for those with compromised immune systems (eg. AIDS, transplant and cancer patients). These fungi cause disease by evading the immune system whilst deriving nutrients for growth. Some fungi evade the immune system by residing within host cells; a hostile and nutrient poor environment. This project will study a pathway that we have shown is required for growth inside host cells. This knowledge will open new avenues for treatment.