Cellular and molecular mechanisms of fungal infection pathogenesis and therapy

对于免疫力低下的患者，如化疗或移植患者，真菌感染是严重的问题。需要更有效的抗真菌治疗。我们将研究斑马鱼胚胎中真菌感染的模型，该模型重现了人类青霉病。这项研究将研究感染是如何建立的，以及不同类型的白细胞如何帮助或阻碍感染的建立。这一结果将指出治疗严重真菌感染的新方法。

Fungal infections are serious problems for patients with depressed immunity such as chemotherapy or transplant patients. More effective antifungal treatments are needed. We will study a model of fungal infection in zebrafish embryos that recapitulates human penicilliosis. The research will study how the infection establishes and how different types of white blood cells either help or hinder infection establishment. The results will point to new approaches for treating serious fungal infections.