Molecular mechanisms of ivermectin resistance in the ectoparasitic mite, Sarcoptes scabiei

外寄生螨疥螨对伊维菌素耐药的分子机制

• 批准号: nhmrc : 490345
• 负责人: Dr Kate Mounsey
• 金额: $ 19.31万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-mechanisms-ivermectin-sarcoptes-scabiei/115439
• 关键词: Molecular; mechanisms; ivermectin; resistance; ectoparasitic

A largely neglected parasitic disease, scabies is a significant disease of children, particularly in remote Aboriginal communities in northern Australia. The recent emergence of ivermectin resistance threatens future control of scabies. This research explores the genetic basis of ivermectin resistance in the scabies mite, developing molecular markers to identify the emergence of resistance in the community, leading to improved tools for resistance management and sustainable treatment strategies.

作为一种在很大程度上被忽视的寄生虫病，麻疹是一种严重的儿童疾病，特别是在澳大利亚北部偏远的土著社区。最近出现的伊维菌素抗药性威胁到未来对麻疹的控制。这项研究探索了伊维菌素耐药的遗传基础，开发了分子标记来识别社区中出现的抗药性，从而改进了抗药性管理和可持续治疗策略的工具。