Botanical Identification, Characterization, Quality Assurance/Ikhlas A. Khan

植物鉴定、表征、质量保证/Ikhlas A. Khan

• 批准号: 8007128
• 负责人: William G Helferich
• 金额: $ 14.7万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8007128
• 关键词: Angelica sinensis; Angelica sinensis preparation; Biological; Botanicals; Data; Dose; Estrogens; Evaluation; Genus Dioscorea; Glycyrrhiza; High Pressure Liquid Chromatography; Instruction; Licorice; Methodology; Methods; Microscopic; Phytochemical; Plants; Progress Reports; Quality Control; Research; Research Design; Research Project Grants; Sampling; Specimen; Techniques; Tissues; Yam - dietary; dietary supplements; meetings; quality assurance; research study; scale up

PROJECT SUMMARY (See instructions): In order to have a complete understanding of the botanical reference material selected for study under this Botanical Research Center (BRC), Licorice - Glycyrrhiza glabra Linne var glabra. Wild Yam - Dioscorea villosa L., and Dong Quai - Angelica sinensis (Oliv.) Diels, one needs to fully evaluate not only the morphological makeup of the material but also examine the requisite phytochemical proflle and conduct the subsequent analytical assessment ofthe relevant "bio-markers" for each selected species. To accomplish this task, the Botanical Identiflcation, Characterization Quality Assurance and Quality Control Core (Core A) will meet the following speciflc aims. Speciflc Aim 1. Authenticate botanical samples and extracts ofthe aforementioned species through the utilization of appropriate microscopic techniques and/or phytochemical evaluation (HPTLC, HPLC, etc.). Specific Aim 2. Provide authenticated plant specimens, bulk extracts, semi-purified fracfions, and pure compounds of the listed plants and closely related species for biological assessment within the other projects. Isolated pure compounds will be utilized for refinement of analytical methodologies and related speciation analysis. Specific Aim 3. Provide scale up extracfion and isolation capabilifies as needed for the requisite projects. Each of the outiined aims will be tailored to suit the particular research requirements for the associated Research Projects 1, 2 and 3.

项目总结（见说明）： 为了全面了解本植物学研究中心（BRC）所选的植物学参考材料，光叶甘草（Licenza glabra Linne var glabra）。野山药-毛萼野山药，和当归（Angelica sinensis（Oliv.）第二，人们不仅需要全面评估材料的形态构成，还需要检查必要的植物化学特征，并对每个选定物种的相关“生物标记物”进行后续分析评估。完成 这项任务，即植物鉴定、表征质量保证和质量控制核心（核心A）将满足以下特定目标。 具体目标1.鉴定植物样本和提取物上述物种通过 利用适当的显微技术和/或植物化学评价（HPTLC、HPLC等）。 具体目标2。为其他项目的生物评估提供所列植物和密切相关物种的经鉴定的植物标本、大量提取物、半纯化组分和纯化合物。分离的纯化合物将用于改进分析方法和相关的形态分析。 具体目标3。根据项目的需要，提供扩大规模的提取和分离能力。 每一个既定目标都将根据相关研究项目1、2和3的特定研究要求进行调整。