Pharmacokinetics, Bioavailability, and Metabolism/Daniel R. Doerge

药代动力学、生物利用度和代谢/Daniel R. Doerge

• 批准号: 8007129
• 负责人: William G Helferich
• 金额: $ 8.33万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8007129
• 关键词: Angelica sinensis preparation; Animal Model; Biological; Biological Availability; Botanicals; Brain region; Cells; Data; Dose; Drug Kinetics; Estradiol; Estrogen Receptors; Estrogens; Evaluation; Exhibits; Isotopes; Laboratories; Licorice; Ligands; Mammary gland; Metabolic; Metabolism; Mus; Oral; Plasma; Pre-Clinical Model; Rattus; Research; Research Project Grants; Risk; Rodent; Safety; Source; Tissues; Uterus; Woman; Work; Yam - dietary; analytical method; base; body system; dietary supplements; equol; pre-clinical; response; tandem mass spectrometry; tool

The Pharmacokinefics, Bioavailability, and Metabolism Core will provide the Botanical Research Center with validated analytical methods based on tandem mass spectrometry and isotope dilufion to idenfify and quantify the various botanical estrogens and potenfial metabolites in experimental pre-clinical models from Research Projects 2 and 3. The internal exposure data collected from plasma and specific target fissues, including mammary gland, uterus, and brain regions, will be used to determine appropriate dosing and possible differences in bioavailability for whole botanicals vs. purified acfive ingredients. These tools will provide a comprehensive evaluation of pharmacokinetics and metabolism to be included in all assessments of botanical estrogens in the various organ systems.

药代动力学、生物利用度和代谢核心将为植物研究中心提供基于串联质谱和同位素稀释的经验证的分析方法，以验证和定量研究项目2和3的实验性临床前模型中的各种植物雌激素和潜在代谢物。从血浆和特定靶区（包括乳腺、子宫和脑区域）收集的内部暴露数据将用于确定全植物药与纯化的ACFive成分的适当剂量和生物利用度的可能差异。这些工具将提供药代动力学和代谢的综合评价，包括在各种器官系统中植物雌激素的所有评估中。