Molecular mechanisms that mediate the anti-osteosarcoma properties of pigment epithelium-derived factor (PEDF)

癌症源于一系列基因的改变，导致细胞不受控制地分裂。骨肉瘤是一种涉及骨骼的癌症，可迅速扩散到周围和远处组织。许多介质已被确定为能够对这种异常细胞分裂提供一些调节。色素上皮衍生因子就是这样一种蛋白质，进一步了解它是如何实现这一目标的，可以用于开发靶向骨肉瘤治疗。

Cancer results from a sequence of alterations to genes which lead to abnormal cells dividing without control. Osteosarcoma is a cancer involving bone and can rapidly spread to surrounding and distant tissues. A number of mediators have been identified as being able to provide some regulation of this abnormal cell division. Pigment epithelium-derived factor is one such protein and further understanding of how it achieves this could be used for the development of targeted osteosarcoma treatment.