Molecular mechanisms of mitotic progression and the anti-cancer properties of anti-mitotic agents

有丝分裂进展的分子机制和抗有丝分裂剂的抗癌特性

• 批准号: nhmrc : 1069264
• 负责人: A/Pr Megan Chircop
• 金额: $ 31.11万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-mechanisms-mitotic-mitotic-agents/455382
• 关键词: Molecular; mechanisms; mitotic; progression; anti

Mitosis is the final stage of the cell division cycle that produces two daughter cells. Incorrect localisation and modification of proteins that regulate this process cause cell division errors potentially leading to cancer. This project will characterise how key mitotic proteins co-operatively function to complete this process. This research will increase our understanding of the cell division errors that contribute to cancer development, ultimately identifying new targets for cancer therapy.

有丝分裂是细胞分裂周期的最后阶段，产生两个子细胞。调节这一过程的蛋白质的不正确定位和修饰导致细胞分裂错误，可能导致癌症。这个项目将研究关键的有丝分裂蛋白如何协同作用来完成这一过程。这项研究将增加我们对导致癌症发展的细胞分裂错误的理解，最终确定癌症治疗的新靶点。