The molecular mechanisms of abscission to complete cytokinesis

脱落完成胞质分裂的分子机制

• 批准号: nhmrc : 477102
• 负责人: A/Pr Megan Chircop
• 金额: $ 49.1万
• 依托单位: Children's Medical Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-mechanisms-abscission-complete-cytokinesis/95578
• 关键词: molecular; mechanisms; abscission; complete; cytokinesis

Cytokinesis is the final stage of cell division that produces two daughter cells. Incorrect localisation and modification of proteins that regulate this process cause cell division errors potentially leading to cancer. This project will characterise how key cytokinesis proteins function co-operatively to complete cytokinesis. This research will increase our understanding of the cell division errors that contribute to cancer development, ultimately identifying new targets for cancer therapy.

细胞质分裂是细胞分裂的最后阶段，产生两个子细胞。调节这一过程的蛋白质不正确的定位和修饰会导致细胞分裂错误，可能导致癌症。该项目将描述关键细胞分裂蛋白如何协同完成细胞分裂。这项研究将增加我们对导致癌症发展的细胞分裂错误的理解，最终确定癌症治疗的新靶点。