Influence of Metal-Working Fluid Formulations on Dermal Absorption of Biocides
金属加工液配方对杀菌剂皮肤吸收的影响
基本信息
- 批准号:8284171
- 负责人:
- 金额:$ 30.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-08-01 至 2015-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Abstract
The long-term goal is to understand physicochemical and chemical-biological
interactions in a metal-working fluid (MWF) formulation in order to be able to predict
quantitatively how these formulations influence dermal absorption of industrial biocides
used as additives in these chemically complex formulations. Current dermal risk
assessments only evaluate dermal absorption of single chemicals which has limited use
in occupational exposure to chemically complex MWF formulations. The primary
objective of this research project is to utilize the membrane-coated fibers (MCF) to
characterize the distribution behavior between a defined MWF formulation, a MWF
biocide, and an inert membrane and to relate this phase distribution to solvation
parameters within a linear solvation energy relationship (LSER) framework that is also
applicable to dermal permeability. The central hypothesis to be tested is that the
presence of MWF formulations will alter the phase distribution of biocides between the
formulation and the MCF and/or skin. These changes in biocide distribution can be
expressed in terms of interaction coefficients ( values) that can be used in future
extrapolations to a defined formulation scenario and thus can be of value to MWF
formulators and metal fabrication workers by indicating what formulations are more likely
to promote skin penetration and possibly adverse occupational effects. The rationale for
this approach is that MWF formulations can modulate biocide partitioning and diffusion
by quantifiable physicochemical interactions ( values). The MCF approach within the
LSER framework allows for a physicochemical examination of these formulation effects
using a multi-fiber MCF array system and validated in porcine skin diffusion cells and
finally validated in vivo for systemic absorption. The following three specific aims will be
pursued to accomplish the stated objectives: 1) To quantify mixture interactions
influencing transport of MWF biocides between MWF formulations and the
membrane coated fibers (MCF). This first involves calibration of a diverse series of
fibers followed by exposure of a 5-component MCF array to MWF formulations to
provide interaction coefficients ( values) for a defined formulation. 2) To quantify
chemical-biological interactions in a biological membrane system following
exposure to MWF formulations in porcine skin flow-through diffusion cell. Dermal
in vitro experiments will calibrate permeability in the biological system and validate
formulation interaction coefficients in the MCF array for the biocides. 3) To quantify the
effect of MWF formulations on the in vivo dermal absorption of MWF biocides.
This involves comparative analysis of interaction coefficients between the MCF array
and the two biological systems (in vitro and in vivo) and will validate the proposed MCF-
array approach within the LSER framework to predict the dermal permeability of
occupationally relevant toxicants such as MWF biocides in a defined in MWF
formulations.
摘要
长期目标是了解物理化学和化学生物学
金属加工液(MWF)配方中的相互作用,以便能够预测
这些制剂如何定量地影响工业杀生物剂的皮肤吸收
在这些化学复杂的配方中用作添加剂。当前皮肤风险
评估仅评价使用有限的单一化学品的皮肤吸收
在职业暴露于化学复杂的MWF制剂。主
本研究项目的目的是利用膜涂层纤维(MCF),
表征定义的MWF配方、MWF
杀生物剂和惰性膜,并将该相分布与溶剂化相关联
线性溶剂化能量关系(LSER)框架内的参数,
适用于皮肤渗透性。要检验的中心假设是,
MWF制剂的存在将改变杀生物剂在微胶囊之间的相分布。
在一些实施方案中,所述药物组合物可用于配制物和MCF和/或皮肤。杀生物剂分布的这些变化可以是
以相互作用系数表示( 值),可用于将来
外推到定义的配方方案,因此对MWF有价值
配方设计师和金属加工工人,指出哪些配方更有可能
促进皮肤渗透和可能的不良职业影响。的理由
这种方法是MWF制剂可以调节杀生物剂的分配和扩散
通过可量化的物理化学相互作用( 值)。多边基金办法
LSER框架允许对这些制剂效应进行理化检查
使用多纤维MCF阵列系统并在猪皮肤扩散池中验证,
最终在体内验证全身吸收。以下三个具体目标
追求实现既定目标:1)量化混合物的相互作用
影响MWF杀生物剂在MWF制剂和微生物制剂之间的运输。
膜涂层纤维(MCF)。这首先涉及校准一系列不同的
纤维,然后将5组分MCF阵列暴露于MWF制剂,
提供相互作用系数( 值)用于定义的配方。2)量化
生物膜系统中的化学-生物相互作用,
在猪皮流通扩散池中暴露于MWF制剂。真皮
体外实验将校准生物系统中的渗透性并验证
用于杀生物剂的MCF阵列中的制剂相互作用系数。3)量化
MWF制剂对MWF杀生物剂的体内皮肤吸收的影响。
这涉及到MCF阵列之间的相互作用系数的比较分析
和两个生物系统(体外和体内),并将验证拟议的MCF-
在LSER框架内的阵列方法来预测皮肤渗透性,
职业相关毒物,如MWF中定义的MWF杀生物剂
制剂。
项目成果
期刊论文数量(16)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Quantification of chemical mixture interactions modulating dermal absorption using a multiple membrane fiber array.
使用多膜纤维阵列对调节皮肤吸收的化学混合物相互作用进行量化。
- DOI:10.1021/tx7002118
- 发表时间:2008
- 期刊:
- 影响因子:4.1
- 作者:Baynes,RonaldE;Xia,XinRui;Imran,Mudassar;Riviere,JimE
- 通讯作者:Riviere,JimE
Predicting dermal permeability of biocides in commercial cutting fluids using a LSER approach.
使用 LSER 方法预测商用切削液中杀菌剂的皮肤渗透性。
- DOI:10.1016/j.toxlet.2007.09.005
- 发表时间:2007
- 期刊:
- 影响因子:3.5
- 作者:Vijay,Vikrant;YeattsJr,JamesL;Riviere,JimE;Baynes,RonaldE
- 通讯作者:Baynes,RonaldE
Physicochemical determinants of linear alkylbenzene sulfonate (LAS) disposition in skin exposed to aqueous cutting fluid mixtures.
暴露于水性切削液混合物的皮肤中直链烷基苯磺酸盐 (LAS) 分布的物理化学决定因素。
- DOI:10.1191/0748233702th147oa
- 发表时间:2002
- 期刊:
- 影响因子:1.9
- 作者:Baynes,RonaldE;Brooks,JamesD;Barlow,BethM;Riviere,JimE
- 通讯作者:Riviere,JimE
Determination of the partition coefficients and absorption kinetic parameters of chemicals in a lipophilic membrane/water system by using a membrane-coated fiber technique.
- DOI:10.1016/j.ejps.2004.09.004
- 发表时间:2005
- 期刊:
- 影响因子:0
- 作者:X. Xia;R. Baynes;N. Monteiro-Riviere;J. Riviere
- 通讯作者:X. Xia;R. Baynes;N. Monteiro-Riviere;J. Riviere
A compartment model for the membrane-coated fiber technique used for determining the absorption parameters of chemicals into lipophilic membranes.
膜涂层纤维技术的隔室模型,用于确定化学物质进入亲脂膜的吸收参数。
- DOI:10.1023/b:pham.0000036907.02901.f7
- 发表时间:2004
- 期刊:
- 影响因子:3.7
- 作者:Xia,Xin-Rui;Baynes,RonaldE;Monteiro-Riviere,NancyA;Riviere,JimE
- 通讯作者:Riviere,JimE
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Ronald E Baynes其他文献
Ronald E Baynes的其他文献
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{{ truncateString('Ronald E Baynes', 18)}}的其他基金
Influence of Metal-Working Fluid Formulations on Dermal Absorption of Biocides
金属加工液配方对杀菌剂皮肤吸收的影响
- 批准号:
7887567 - 财政年份:2010
- 资助金额:
$ 30.3万 - 项目类别:
Influence of Metal-Working Fluid Formulations on Dermal Absorption of Biocides
金属加工液配方对杀菌剂皮肤吸收的影响
- 批准号:
8131821 - 财政年份:2010
- 资助金额:
$ 30.3万 - 项目类别:
Mixture Effects on the Dermal Absorption of Biocides
混合物对杀菌剂皮肤吸收的影响
- 批准号:
7249351 - 财政年份:2000
- 资助金额:
$ 30.3万 - 项目类别:
Mixture Effects on the Dermal Absorption of Biocides
混合物对杀菌剂皮肤吸收的影响
- 批准号:
7114810 - 财政年份:2000
- 资助金额:
$ 30.3万 - 项目类别:
Mixture Effects on the Dermal Absorption of Biocides
混合物对杀菌剂皮肤吸收的影响
- 批准号:
6980338 - 财政年份:2000
- 资助金额:
$ 30.3万 - 项目类别:
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Influence of Metal-Working Fluid Formulations on Dermal Absorption of Biocides
金属加工液配方对杀菌剂皮肤吸收的影响
- 批准号:
7887567 - 财政年份:2010
- 资助金额:
$ 30.3万 - 项目类别: