TRIAD CMI Scientific Core

TRIAD CMI 科学核心

• 批准号: 8378751
• 负责人: LOREN D. FAST
• 金额: $ 39.91万
• 依托单位: UNIVERSITY OF RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8378751
• 关键词: Address; Antigens; Binding; Biological Assay; Breeding; Burkholderia; Cellular Immunity; Chronic; Computer Simulation; Cryopreservation; Development; Disease; Engineering; Epitopes; Equipment; Evaluation; Farming environment; Helicobacter pylori; Hepatitis C virus; Human; Immune response; Immunology; In Vitro; Leukocytes; Measures; Methods; Mus; Procedures; Process; Research; Research Infrastructure; Resources; Specific qualifier value; Technology; Testing; Ticks; Transgenic Mice; Transgenic Organisms; Tularemia; Vaccines; Work; cell mediated immune response; cytokine; design; in vivo; instrumentation; pathogen; programs; research and development; technology development; vaccine candidate; vaccine development

The theme of the overall program focuses on development of a broad spectrum vaccine technology process employing immunoinformatics tools for epitope prediction. Many of the processes and procedures to be employed by projects within the program employ human leucocytes, HLA transgenic mice, and assays for characterization of cell mediated immune responses to verify the in silico predictions and to analyze immune responses engendered by vaccine candidates. This cell mediated immunity scientific core is designed to provide the equipment, staffing, and capabilities required to support these verification processes and analyses. All research and technology development projects within the program specify that some or all of the resources provided by this core will be employed by each project. The core capabilities and infrastructure provided by this core will include the following: 1) Flow cytometric and cytokine bead analysis 2) ELISpot assay analysis 3) Human leucocyte cryopreservation and short term storage 4) Insuring program access to required HLA transgenic mice through support of HLA transgenic murine breeding colony at Taconic Farms

整个方案的主题侧重于发展一种广谱疫苗技术进程