TEMPORAL DISSECTION OF AUTOPHAGOSOME FORMATION IN SACCHAROMYCES CEREVISIAE
TEMPORAL DISSECTION OF AUTOPHAGOSOME FORMATION IN SACCHAROMYCES CEREVISIAE
批准号:
8362557
负责人:
DANIEL J. KLIONSKY
金额:
$2.13万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-05-01 至 2012-04-30
关键词:
AutophagocytosisAutophagosomeBiogenesisCell physiologyCellular StructuresComplexDissectionFundingGenesGoalsGrantHumanLocationMembraneNational Center for Research ResourcesNaturePathway interactionsPhysiologicalPlayPrincipal InvestigatorProcessProteinsResearchResearch InfrastructureResourcesRoleSaccharomyces cerevisiaeSiteSourceUnited States National Institutes of HealthYeast Model SystemYeastscostprotein function
中文摘要
这个子项目是利用这些资源的众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
The goal of this project is to fully explore the physiological functions of autophagy. For this, it is critical to understand the central part of the autophagy pathway, the autophagosome formation process. To date, approximately 30 autophagy-related (ATG) genes have been identified using yeast model systems. Among them, 15 are conserved from yeast to human and are essential for autophagosome formation; the products of these genes are termed the core machinery proteins. It was hypothesized that these core machinery proteins function at the phagophore assembly site (PAS).
The PAS is essentially uncharacterized, even though it is thought to play a fundamental role in autophagosome biogenesis. Thus, there are basic questions such as the membrane nature of this site, whether the phagophore expands by vesicular fusion, and whether the Atg proteins (almost all of which associate in large part with the PAS) are in complexes at particular locations at the PAS, such as at the growing ends of the phagophore (note that the exact relationship between the PAS and the phagophore is not known; the PAS may develop into a phagophore, or may provide membrane to a separate site that corresponds to the phagophore).
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会议论文
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批准号:10620351
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项目类别:
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资助金额:$76.6万
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财政年份:2019
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批准号:10166877
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资助金额:$76.69万
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财政年份:2019
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批准号:10408006
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项目类别:
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资助金额:$76.58万
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依托单位:
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批准号:9912809
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资助金额:$76.67万
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财政年份:2019
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依托单位:
Equipment Supplement: The mechanism and regulation of autophagy
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批准号:10387221
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项目类别:
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资助金额:$24.73万
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财政年份:2019
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负责人:DANIEL J. KLIONSKY
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依托单位:
Gordon Conference-Autophagy/Stress/Development/Disease
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批准号:6751148
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项目类别:
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资助金额:$0.5万
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财政年份:2003
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负责人:DANIEL J. KLIONSKY
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依托单位:
ALTERNATIVE VACUOLAR TARGETING MECHANISMS IN YEAST
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批准号:2394665
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项目类别:
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资助金额:$6.54万
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财政年份:1991
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负责人:DANIEL J. KLIONSKY
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依托单位:
ALTERNATIVE VACUOLAR TARGETING MECHANISMS IN YEAST
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批准号:2713742
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项目类别:
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资助金额:$22.8万
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财政年份:1991
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负责人:DANIEL J. KLIONSKY
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依托单位:
TARGETING OF VACUOLAR PROTEINS IN YEAST
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批准号:3245088
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项目类别:
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资助金额:$11.96万
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财政年份:1991
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负责人:DANIEL J. KLIONSKY
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依托单位:
Alternative vacuolar targeting mechanisms in yeast
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批准号:7844879
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项目类别:
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资助金额:$70.52万
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财政年份:1991
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负责人:DANIEL J. KLIONSKY
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依托单位:
ALTERNATIVE VACUOLAR TARGETING MECHANISMS IN YEAST
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批准号:6180783
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项目类别:
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资助金额:$16.26万
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财政年份:1991
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负责人:DANIEL J. KLIONSKY
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依托单位:
Alternative vacuolar targeting mechanisms in yeast
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批准号:6751259
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项目类别:
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资助金额:$52.3万
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财政年份:1991
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负责人:DANIEL J. KLIONSKY
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依托单位:
ALTERNATIVE VACUOLAR TARGETING MECHANISMS IN YEAST
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批准号:6519685
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项目类别:
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资助金额:$36.85万
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财政年份:1991
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负责人:DANIEL J. KLIONSKY
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依托单位:
Alternative vacuolar targeting mechanisms in yeast
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批准号:7364721
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项目类别:
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资助金额:$47.89万
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财政年份:1991
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负责人:DANIEL J. KLIONSKY
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依托单位:
Alternative vacuolar targeting mechanisms in yeast
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批准号:7409469
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项目类别:
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资助金额:$19.28万
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财政年份:1991
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负责人:DANIEL J. KLIONSKY
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依托单位:
Alternative Vacuolar Targeting Mechanisms in Yeast
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批准号:8470173
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项目类别:
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资助金额:$63.04万
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财政年份:1991
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负责人:DANIEL J. KLIONSKY
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依托单位:
Alternative vacuolar targeting mechanisms in yeast
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批准号:7628676
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项目类别:
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资助金额:$69.8万
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财政年份:1991
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负责人:DANIEL J. KLIONSKY
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依托单位:
ALTERNATIVE VACUOLAR TARGETING MECHANISMS IN YEAST
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批准号:2430487
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项目类别:
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资助金额:$15.14万
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财政年份:1991
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负责人:DANIEL J. KLIONSKY
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依托单位:
ALTERNATIVE VACUOLAR TARGETING MECHANISMS IN YEAST
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批准号:2192753
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项目类别:
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资助金额:$14.42万
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财政年份:1991
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负责人:DANIEL J. KLIONSKY
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依托单位:
Alternative vacuolar targeting mechanisms in yeast
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批准号:6898344
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项目类别:
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资助金额:$54.53万
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财政年份:1991
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负责人:DANIEL J. KLIONSKY
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依托单位:
海外基金