Molecular mechanisms underlying recovery from general anaesthesia

全身麻醉恢复的分子机制

• 批准号: nhmrc : GNT1103923
• 负责人: A/Pr Bruno van Swinderen
• 金额: $ 33.6万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-mechanisms-underlying-general-anaesthesia/1346316
• 关键词: Molecular; mechanisms; underlying; recovery; general

Even though general anaesthesia is an extremely common and safe procedure, doctors do not really know how it works. We have found that general anaesthetics might work in two steps, by first promoting natural sleep, and then by impairing communication between all nerve cells in the brain. It is this second step that makes surgery possible, but also makes recovery difficult – especially among patients with brain disorders. Understanding these mechanisms will promote better anaesthesia procedures.

尽管全身麻醉是一种非常常见和安全的手术，但医生并不真正知道它是如何工作的。我们发现，全身麻醉可能分两步起作用，首先是促进自然睡眠，然后是损害大脑中所有神经细胞之间的交流。正是这第二步使手术成为可能，但也使康复变得困难-特别是在患有脑部疾病的患者中。了解这些机制将促进更好的麻醉程序。