Scholars' Program in the Genetics and Genomics of Lung Diseases

肺部疾病遗传学和基因组学学者计划

• 批准号: 8121639
• 负责人: Deborah A. Meyers
• 金额: $ 39.85万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-27 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8121639
• 关键词: Appointment; Asthma; Chronic Obstructive Airway Disease; Clinical; Commit; Complex; Critical Care; Development; Doctor of Philosophy; Educational Curriculum; Faculty; Funding; Genetic; Genomics; Goals; Grant; Hereditary Disease; Human; Human Genetics; Immune System Diseases; Journals; Laboratories; Lung; Lung diseases; Master' s Degree; Mentorship; Molecular Medicine; NCI Scholars Program; Peer Review; Physicians; Postdoctoral Fellow; Publications; Pulmonology; Research; Research Personnel; Research Training; Rotation; Scientist; Time; Training; Training Programs; career development; health science research; meetings; programs; respiratory; skills

The goal of this initiative is to increase the number of investigators committed to research in pulmonary diseases by equipping these new investigators with the necessary skills for genetics and genomics research to study complex genetic disease. Our approach to meeting the intent of this initiative is train Scholars in genomics research using the integrated facilities of the Center for Human Genetics and the Division of Pulmonary, Critical Care and Immunologic Diseases in conjunction with one of two already established Master's Degree Programs (Health Sciences Research or Molecular Medicine) which includes a year of research. This curriculum will be supplemented with additional laboratory rotations to train Scholars in the fundamentals of genetics and genomics research. Finally, all Scholars will participate in career development and active research under the mentorship of two faculty supervisors with the goal of publications in peer reviewed journals and the development of independent scientific research skills. We have a strong integrated Center for Human Genomics which is well-funded with a strong emphasis on respiratory genetics, primarily genetics of asthma and, secondary, genetics of COPD. Ten faculty within the Genomics Center have their primary academic appointment in the Pulmonary Section. Currently, postdoctoral fellows have one year of full time research during their clinical training. This training grant would permit these pulmonary trainees to apply for full time research in genomics and pulmonary medicine while completing a masters degree over a two to three year period. Thus, the program can be integrated with the current pulmonary training program to support an additional research training to develop the skills necessary to become an independent physician scientist. Others may enter this program with a PhD with emphasis on respiratory research and will be able to develop skills in genomics research, thus, facilitating research directions and career development.

该计划的目标是通过为这些新研究人员配备遗传学和基因组学研究所需的技能来研究复杂的遗传疾病，从而增加致力于肺部疾病研究的研究人员数量。我们实现这一计划的目的的方法是，利用人类遗传学中心和肺病、重症监护和免疫疾病部门的综合设施，结合两个已经建立的硕士学位课程（健康科学研究或分子医学）之一（其中包括一年的研究），培训基因组学研究的学者。该课程将辅以额外的实验室轮换，以培训学者的遗传学和基因组学研究基础知识。最后，所有学者将在两名导师的指导下参与职业发展和积极研究，目标是在同行评审期刊上发表论文并发展独立的科学研究技能。 我们拥有强大的人类基因组学综合中心，资金充足，重点关注呼吸遗传学，主要是哮喘遗传学，其次是慢性阻塞性肺病遗传学。基因组学中心的十名教员的主要学术任命是在肺科。目前，博士后研究员在临床培训期间有一年的全职研究。这笔培训补助金将允许这些肺部学员申请基因组学和肺部医学的全职研究，同时在两到三年内完成硕士学位。因此，该计划可以与当前的肺部培训计划相结合，以支持额外的研究培训，以培养成为独立医师科学家所需的技能。其他人可能会获得博士学位，重点是呼吸研究，并将能够发展基因组学研究技能，从而促进研究方向和职业发展。

项目成果

Pharmacogenetics and the development of personalized approaches for combination therapy in asthma.

• DOI: 10.1007/s11882-013-0372-x
• 发表时间: 2013-10
• 期刊: CURRENT ALLERGY AND ASTHMA REPORTS
• 影响因子: 5.5
• 作者: Miller, Stacey M.;Ortega, Victor E.
• 通讯作者: Ortega, Victor E.