课题基金 / 基金详情

Regulation of LKB1 and AMPK Signaling by BRAF in Melanoma

Regulation of LKB1 and AMPK Signaling by BRAF in Melanoma
BRAF 对黑色素瘤中 LKB1 和 AMPK 信号传导的调节
批准号:
8106446
负责人:
Bin Zheng
金额:
$24.15万
依托单位国家:
美国
项目类别:
财政年份:
2008
资助国家:
美国
项目状态:
已结题
起止时间:
2008-06-01 至 2013-06-30
关键词:
3T3-L1 Cells5&apos-AMP-activated protein kinaseAMP-activated protein kinase kinaseAbateAcademic Medical CentersAdvisory CommitteesApoptosisAppointmentAreaBRAF geneBiochemicalBiological AssayCDK4 geneCI-1040Cancer BiologyCell Cycle ProgressionCell LineCell ProliferationCell SurvivalCellsClinical ResearchClinical TrialsCollaborationsCollectionCombined Modality TherapyComprehensive Cancer CenterDataDermatologyDoctor of PhilosophyDown-RegulationEnergy MetabolismEnvironmentEnzymesFamilyFatty AcidsFutureGene MutationGenesGenetic DeterminismGoalsGrantHumanIn VitroIncidenceInhibition of Cell ProliferationInstructionKnockout MiceLaboratoriesLightLinkMEKsMaintenanceMalignant - descriptorMalignant NeoplasmsMediatingMelaninsMelanoma CellMentorsMetabolicMetabolismMetforminModificationMolecularMusMutateMutationNeoplasm MetastasisOncogenicPTEN genePathogenesisPathway interactionsPatientsPeutz-Jeghers SyndromePhasePhase I Clinical TrialsPhosphorylationPhosphotransferasesPigmentsPlayProlineProtein BindingProtein KinaseProtein-Serine-Threonine KinasesProteinsProto-Oncogene Proteins B-rafPublicationsRNARegulationReportingResearchResistanceRoleSH3 DomainsSTK11 geneSU 6656SamplingSignal PathwaySignal TransductionSignaling ProteinSkin CancerSrc family kinase inhibitor PP2StressTSC2 geneTestingTherapeuticTimeLineTissue MicroarrayTumor Suppressor ProteinsUniversitiesWorkXenograft ModelXenograft procedureanalogbasecancer typecarcinogenesiscareercell growthdesigngenetic regulatory proteinglucose uptakein vivoinhibitor/antagonistinsightinterestmTOR Signaling Pathwaymedical schoolsmelanocytemelanomamembermolecular pathologymortalitymutantnoveloverexpressionoxidationpost-doctoral trainingpre-clinicalpreclinical studyresearch studyresponsesensorsrc-Family Kinasestherapeutic targettumortumor growthtumorigenesisuptake

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Administrative Core
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    10334982
  • 项目类别:
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  • 财政年份:
    2022
  • 负责人:
    Bin Zheng
  • 依托单位:
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    10334981
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Regulation of interferon signaling in melanoma by the cohesin complex protein STAG2 via 3D genome organization
  • 批准号:
    10905899
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    2022
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    Bin Zheng
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Targeting the LKB1-AMPK pathway in melanoma: Mechanism and preclinical evaluation
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    9690391
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国内基金
海外基金
晚期妊娠维持和抑制早产中cAMP信号活化PR的作用机制研究
  • 批准号:
    81300507
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    22.0万元
  • 批准年份:
    2013
  • 负责人:
    陈黎
  • 依托单位: