Regulation of LKB1 and AMPK Signaling by BRAF in Melanoma

BRAF 对黑色素瘤中 LKB1 和 AMPK 信号传导的调节

• 批准号: 8106446
• 负责人: Bin Zheng
• 金额: $ 24.15万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8106446
• 关键词: 3T3-L1 Cells; 5' -AMP-activated protein kinase; AMP-activated protein kinase kinase; Abate; Academic Medical Centers; Advisory Committees; Apoptosis; Appointment; Area; BRAF gene; Biochemical; Biological Assay; CDK4 gene; CI-1040; Cancer Biology; Cell Cycle Progression; Cell Line; Cell Proliferation; Cell Survival; Cells; Clinical Research; Clinical Trials; Collaborations; Collection; Combined Modality Therapy; Comprehensive Cancer Center; Data; Dermatology; Doctor of Philosophy; Down-Regulation; Energy Metabolism; Environment; Enzymes; Family; Fatty Acids; Future; Gene Mutation; Genes; Genetic Determinism; Goals; Grant; Human; In Vitro; Incidence; Inhibition of Cell Proliferation; Instruction; Knockout Mice; Laboratories; Light; Link; MEKs; Maintenance; Malignant - descriptor; Malignant Neoplasms; Mediating; Melanins; Melanoma Cell; Mentors; Metabolic; Metabolism; Metformin; Modification; Molecular; Mus; Mutate; Mutation; Neoplasm Metastasis; Oncogenic; PTEN gene; Pathogenesis; Pathway interactions; Patients; Peutz-Jeghers Syndrome; Phase; Phase I Clinical Trials; Phosphorylation; Phosphotransferases; Pigments; Play; Proline; Protein Binding; Protein Kinase; Protein-Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins B-raf; Publications; RNA; Regulation; Reporting; Research; Resistance; Role; SH3 Domains; STK11 gene; SU 6656; Sampling; Signal Pathway; Signal Transduction; Signaling Protein; Skin Cancer; Src family kinase inhibitor PP2; Stress; TSC2 gene; Testing; Therapeutic; TimeLine; Tissue Microarray; Tumor Suppressor Proteins; Universities; Work; Xenograft Model; Xenograft procedure; analog; base; cancer type; carcinogenesis; career; cell growth; design; genetic regulatory protein; glucose uptake; in vivo; inhibitor/antagonist; insight; interest; mTOR Signaling Pathway; medical schools; melanocyte; melanoma; member; molecular pathology; mortality; mutant; novel; overexpression; oxidation; post-doctoral training; pre-clinical; preclinical study; research study; response; sensor; src-Family Kinases; therapeutic target; tumor; tumor growth; tumorigenesis; uptake