Injury, Ischemia and Inflammation: A Translational Approach to Trauma Treatment

描述(由申请人提供)：创伤是美国一个主要的健康和社会问题。我们拟议的博士后培训计划满足了国家在创伤研究方面的严重需求，旨在根据与临床相关的平民和军事创伤实验室模型的目标，开发和评估新的监测战略、复苏、免疫调节和止血的新方法，以帮助将实验室结果转化到床边。这个创伤方面的博士后培训项目致力于将新想法从工作台转化到床边。每个实习生将完成为期两年的临床研究奖学金和理学硕士学位，总共有10名实习生在5年的项目期间完成项目。该培训计划将得到德克萨斯州圣安东尼奥创伤研究所(TRISAT)成员机构、该市三个I级创伤中心和美国陆军外科研究所(USAISR)的成熟的国会支持的临床合作机构的支持，USAISR是国防部(DOD)中完全致力于改善战斗伤亡护理的唯一研究实验室。UTHSCSA外科部门和TRISAT联盟是唯一有资格填补现有培训缺口的机构，原因有三。首先，TRISAT联盟为庞大的患者群体(每年超过8000例创伤病例)提供物质资源，以及一支高素质和敬业的外科医生、科学家和其他专家团队，他们涵盖了与创伤和危重护理相关的广泛主题。其次，TRISAT创伤医院与UTHSCSA合作，帮助改善战场准备情况和创伤战斗外科护理的结果。第三，UTHSCSA在与损伤、缺血和炎症相关的其他领域，包括传染病、肿瘤学、成像、牙科和衰老方面，有着悠久而成功的翻译研究历史，这些学科的几名研究人员致力于在基础和临床实验室指导博士后实习生。UTHSCSA外科部门承诺对所有住院医生进行为期两年的翻译研究培训(在住院医生第二年之后)，并要求所有住院医生完成临床调查理学硕士学位。如果我们想要改善结果，降低创伤死亡率，我们必须拥有一支训练有素的危重护理和创伤研究方面的内科科学家队伍。填补目前全国在培训方面的空白尤其重要，因为创伤是美国一个主要的健康和社会问题。事实上，创伤超过了因癌症和心脏病而失去的生命年数的总和，在美国每年造成的损失超过2600亿美元。

DESCRIPTION (provided by applicant): Trauma is a leading health and social issue in the United States. Our proposed postdoctoral training program fulfills a serious national need in trauma research, with aims to develop and evaluate new monitoring strategies, novel methods of resuscitation, immunomodulation and hemostasis based on targets in clinically-relevant laboratory models of civilian and military trauma that can help translate the laboratory findings to the bedside. This postdoctoral training program in trauma is dedicated to translating new ideas from bench top to bedside. Each trainee will complete a 2-year fellowship and a Master's of Science in Clinical Investigation with a total of 10 trainees completing the program over the 5- year project period. The training program will be supported by the Trauma Institute of San Antonio, Texas (TRISAT) member institutions; an established congressionally-supported clinical cooperative of the city's three Level I trauma centers and United States Army Institute of Surgical Research (USAISR), a unique research laboratory in the Department of Defense (DOD) dedicated entirely to improving combat casualty care. The UTHSCSA Department of Surgery and the TRISAT consortium are uniquely qualified to fill the existing training gap for three reasons. First, the TRISAT consortium serves a large patient population (more than 8,000 trauma cases per year) with the physical resources and a highly qualified and dedicated staff of surgeons, scientists, and other experts who span a broad spectrum of topics related to trauma and critical care. Second, the TRISAT trauma hospitals work with the UTHSCSA to help improve battlefield readiness and outcome of trauma combat surgical care. Third, the UTHSCSA has had a long, successful history of translational research in other fields related to injury, ischemia and inflammation, including infectious disease, oncology, imaging, dentistry, and aging and several researchers in these disciplines have committed to mentor the postdoctoral trainees in their basic and clinical laboratories. The UTHSCSA Surgery Department has committed to training all residents in translational research for two years (following the second year of residency) as well as requiring that all residents complete the Master's of Science in Clinical Investigation. We must have a well-trained cadre of physician-scientists in critical care and trauma research if we are going to have improved outcomes and reduce mortality from trauma. Filling the current national gap in training is especially important because trauma is a leading health and social issue in the U.S. In fact, trauma exceeds years of life lost from cancer and heart disease combined and results in annual cost of over $260 billion in the United States.